Department of Laboratory Medicine, Region Jönköping County, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden,
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden,
Oncology. 2020;98(1):42-47. doi: 10.1159/000502651. Epub 2019 Aug 22.
Smoking induces inflammation and an immune response. A cancer-related inflammatory response has been seen in smoking and nonsmoking head and neck squamous cell carcinoma (HNSCC) patients.
The aim of this study was to analyze the possible separated effects of smoking or HNSCC on 18 inflammatory or immune regulatory biomarkers.
Fifty-one nonsmoking and 36 smoking pretreated HNSCC patients and 101 nonsmoking and 39 smoking controls were included in this study. The levels of 18 inflammatory or immune regulatory biomarkers were analyzed. A multivariable linear regression model was used to predict the impact of smoking and HNSCC on the levels of the biomarkers.
Smoking had the highest impact on total WBC, IFN-γ, and MCP-1 levels. The highest impact of HNSCC was found on neutrophils, neutrophil-to-lymphocyte ratio, HsCRP, MIP-1b, and TNF-α levels.
IdentifyingHNSCC or smoking-related inflammatory biomarkers might contribute to the understanding of the immune response in HNSCC patients. This study could provide information of inflammatory biomarkers in HNSCC patients.
吸烟可引起炎症和免疫反应。在吸烟和非吸烟的头颈部鳞状细胞癌（HNSCC）患者中均观察到与癌症相关的炎症反应。
本研究旨在分析吸烟或 HNSCC 对 18 种炎症或免疫调节生物标志物的可能单独影响。
本研究纳入了 51 名不吸烟的 HNSCC 预处理患者、36 名吸烟的 HNSCC 预处理患者、101 名不吸烟的对照者和 39 名吸烟的对照者。分析了 18 种炎症或免疫调节生物标志物的水平。采用多变量线性回归模型来预测吸烟和 HNSCC 对生物标志物水平的影响。
吸烟对总白细胞计数、IFN-γ 和 MCP-1 水平的影响最大。HNSCC 对中性粒细胞、中性粒细胞与淋巴细胞比值、HsCRP、MIP-1b 和 TNF-α水平的影响最大。
确定与 HNSCC 或吸烟相关的炎症生物标志物可能有助于了解 HNSCC 患者的免疫反应。本研究可为 HNSCC 患者的炎症生物标志物提供信息。
