Ikadai H, Ajisawa C, Taya K, Imamichi T
Imamichi Institute for Animal Reproduction, Ibaraki, Japan.
J Reprod Fertil. 1988 Nov;84(2):701-7. doi: 10.1530/jrf.0.0840701.
A new rat line (TS inbred rats) showing uni- or bilateral ectopic scrota in about 70% of the males was established. Ectopic scrota were elongated pouches of the thin muscle layer under the suprainguinal body skin, in which hypoplastic testes and epididymides were seen. Genetic analysis revealed that the ectopic scrotum was controlled by multiple genes. Groups of 5 normal, uni- and bilaterally affected rats were killed at 25 weeks of age. Histologically, ectopic testes of uni- and bilaterally affected rats showed arrest of spermatogenesis at the primary spermatocyte stage. Contralateral testes of unilaterally affected rats were normally descended and showed normal spermatogenesis. No abnormality was seen in the urinary system. Plasma concentrations of FSH were significantly elevated in bilaterally affected rats but plasma concentrations of testosterone and LH were unchanged in uni- and bilaterally affected rats. Pituitary contents of LH and FSH were significantly elevated in bilaterally affected rats. The endocrinological status of TS inbred rats was therefore similar to that of experimentally induced cryptorchid rats.
建立了一种新的大鼠品系（TS近交系大鼠），约70%的雄性大鼠出现单侧或双侧阴囊异位。异位阴囊是腹股沟上体皮肤下薄肌肉层的细长袋状结构，其中可见发育不全的睾丸和附睾。遗传分析表明，异位阴囊受多个基因控制。在25周龄时处死5组正常、单侧和双侧受影响的大鼠。组织学上，单侧和双侧受影响大鼠的异位睾丸在初级精母细胞阶段出现精子发生停滞。单侧受影响大鼠的对侧睾丸正常下降，精子发生正常。泌尿系统未见异常。双侧受影响大鼠的促卵泡激素血浆浓度显著升高，但单侧和双侧受影响大鼠的睾酮和促黄体生成素血浆浓度未发生变化。双侧受影响大鼠的垂体促黄体生成素和促卵泡激素含量显著升高。因此，TS近交系大鼠的内分泌状态与实验诱导的隐睾大鼠相似。
