Popovski Vladimir, Dvojakovska Suzana, Benedetti Alberto, Panchevski Goran, Stamatoski Aleksandar, Janevska Vesna
Clinic for Maxillofacial Surgery, Faculty of Dental Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Macedonia.
Institute of Pathology, Faculty of Medicine, Ss Cyril and Methodius University of Skopje, Skopje, Macedonia.
Ann Med Surg (Lond). 2019 Jul 13;45:95-97. doi: 10.1016/j.amsu.2019.07.021. eCollection 2019 Sep.
Solitary plasmacytoma (SP) is an early-stage plasma cell malignancy that is in between monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) along the spectrum of plasma cell disorders. SPs can be divided into 2 groups according to location: solitary bone plasmacytoma (SBP) - these occur most commonly in the vertebrae and secondarily in long bones, and extramedullary plasmacytoma (EMP) - these encompass all nonosseus SPs. The etiology is still unknown, and they generally display a destructive course with preponderance of males. Both lesions present a risk of progression to multiple myelom. Its presence in jaws is extremely rare and when it is seen, angulus and ramus mandible are most common sites of occurrence. Histopathological examination and systemic investigation are mandatory for confirmation but support of immunohistochemistry positivity for CD138 was also done for establishing the final diagnosis.
孤立性浆细胞瘤（SP）是一种早期浆细胞恶性肿瘤，在浆细胞疾病谱中处于意义未明的单克隆丙种球蛋白病（MGUS）和多发性骨髓瘤（MM）之间。根据部位，SP可分为两组：孤立性骨浆细胞瘤（SBP）——最常见于椎体，其次是长骨；髓外浆细胞瘤（EMP）——包括所有非骨SP。病因仍不明，通常呈破坏性病程，男性居多。两种病变都有进展为多发性骨髓瘤的风险。其在颌骨中极为罕见，一旦出现，下颌角和下颌支是最常见的发生部位。组织病理学检查和全身检查对于确诊是必需的，但为了确立最终诊断，也进行了支持CD138免疫组化阳性的检查。
