Nicodemus Natalie Eleanor, Becerra Sergio, Kuhn Taylor P, Packham Hannah R, Duncan John, Mahdavi Kennedy, Iovine Jessica, Kesari Santosh, Pereles Scott, Whitney Mike, Mamoun Michael, Franc Daniel, Bystritsky Alexander, Jordan Sheldon
Neurological Associates - The Interventional Group, USA, Los Angeles, CA.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA.
Alzheimers Dement (N Y). 2019 Aug 8;5:374-381. doi: 10.1016/j.trci.2019.06.007. eCollection 2019.
Preclinical studies support investigation of focused ultrasound for breakdown of cerebral pathologies in neurodegenerative conditions including Alzheimer's disease (AD) and Parkinson's disease (PD).
A focused transcranial Doppler device with probes (2 MHz, 520 mW/cm) affixed bilaterally was used to target the hippocampus (AD) or substantia nigra (PD) with functional magnetic resonance imaging navigation for enhanced plaque removal. A total of 22 patients (n = 11 AD, n = 11 PD) underwent 8 consecutive, weekly, 1-hour treatments wherein sleep was encouraged naturally or pharmacologically. Cognitive and motor functioning assessment was carried out using standardized evaluations at baseline and conclusion.
Of all, 62.5% of patients had one or more improved cognitive scores without data incongruence, 87% had stable or improved fine motor scores, and 87.5% had stable or improved gross motor scores. No adverse events were reported.
The safety of focused transcranial Doppler and possible enhancement in patient functioning were suggested by outcome data.
临床前研究支持对聚焦超声用于分解包括阿尔茨海默病（AD）和帕金森病（PD）在内的神经退行性疾病中的脑部病变进行研究。
使用双侧固定有探头（2兆赫，520毫瓦/平方厘米）的聚焦经颅多普勒设备，通过功能磁共振成像导航靶向海马体（AD）或黑质（PD），以增强斑块清除。共有22名患者（n = 11名AD患者，n = 11名PD患者）接受了连续8周、每周1小时的治疗，其中鼓励自然睡眠或使用药物辅助睡眠。在基线和治疗结束时使用标准化评估进行认知和运动功能评估。
总体而言，62.5%的患者有一项或多项认知评分改善且数据无不一致情况，87%的患者精细运动评分稳定或改善，87.5%的患者粗大运动评分稳定或改善。未报告不良事件。
结果数据表明聚焦经颅多普勒的安全性以及患者功能可能得到改善。
