Manabe Yuta
Department of Dementia and Geriatric Medicine, Division of Advanced Clinical Medicine, Kanagawa Dental University School of Dentistry, Yokosuka, Kanagawa, Japan.
Alzheimer Dis Assoc Disord. 2025;39(1):33-38. doi: 10.1097/WAD.0000000000000652. Epub 2024 Nov 26.
The potential of Ultra-Ma, an ultrasonic head stimulator, for the supplementary treatment of dementia with Lewy bodies (DLB) was evaluated in patients with various symptoms under poor control by drug therapy.
Patients with DLB treated with choline esterase inhibitor or L-DOPA, either alone or in combination, and who met inclusion criteria were enrolled. Four weeks of placebo stimulation was followed by 8 weeks of active ultrasonic stimulation and a 4-week follow-up. Primary endpoints were the effects of ultrasonic head stimulation on both cognitive dysfunction and behavioral and psychological symptoms of dementia (BPSD). Cognitive dysfunction was evaluated using the Japanese versions of the Mini-Mental State Examination and Montreal Cognitive Assessment, and BPSD was assessed using the Neuropsychiatric Inventory Brief Questionnaire Form. For cognitive fluctuations, the Cognitive Fluctuation Inventory served as an index. Improvements in parkinsonism, activities of daily living, and caregiver burden were examined as secondary endpoints.
Twelve patients were enrolled. The primary endpoint was significantly improved during the active stimulation period, as were secondary endpoint ratings for parkinsonism and caregiver burden. No notable adverse events occurred.
The findings suggest that ultrasonic head stimulation has supplementary potential when combined with drug treatment in DLB.
在药物治疗控制不佳的有各种症状的患者中，评估了超声头部刺激器Ultra - Ma对路易体痴呆（DLB）的辅助治疗潜力。
纳入单独或联合使用胆碱酯酶抑制剂或左旋多巴治疗且符合纳入标准的DLB患者。先进行4周的安慰剂刺激，随后进行8周的主动超声刺激以及4周的随访。主要终点是超声头部刺激对认知功能障碍以及痴呆的行为和心理症状（BPSD）的影响。使用日语版简易精神状态检查表和蒙特利尔认知评估量表评估认知功能障碍，使用神经精神科问卷简表评估BPSD。对于认知波动，以认知波动量表作为指标。将帕金森症状、日常生活活动能力和照料者负担的改善情况作为次要终点进行检查。
共纳入12例患者。在主动刺激期间，主要终点有显著改善，帕金森症状和照料者负担的次要终点评分也有改善。未发生明显不良事件。
研究结果表明，超声头部刺激与DLB的药物治疗联合使用时具有辅助治疗潜力。
