School of Physics, Faculty of Sciences, Aristotle University of Thessaloniki, 54124, Thessaloníki, Greece.
Department of Fixed Prosthesis and Implant Prosthodontics, School of Health Sciences, Faculty of Dentistry, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.
J Mater Sci Mater Med. 2019 Aug 22;30(9):98. doi: 10.1007/s10856-019-6297-8.
Calcium magnesium silicate glasses could be suggested for the synthesis of scaffolds for hard tissue regeneration, as they present a high residual glassy phase, high hardness values and hydroxyapatite-forming ability. The use of trace elements in the human body, such as Cu, could improve the biological performance of such glasses, as Cu is known to play a significant role in angiogenesis. Nano-bioceramics are preferable compared to their micro-scale counterparts, because of their increased surface area, which improves both mechanical properties and apatite-forming ability due to the increased nucleation sites provided, their high diffusion rates, reduced sintering time or temperature, and high mechanical properties. The aim of the present work was the evaluation of the effect of different ratios of Ethanol/TEOS and total amount of the inserted ammonia to the particle size, morphology and bioactive, hemolytic and antibacterial behavior of nanoparticles in the quaternary system SiO-CaO-MgO-CuO. Different ratios of Ethanol/TEOS and ammonia amount affected the size and morphology of bioactive nanopowders. The optimum materials were synthesized with the highest ethanol/TEOS ratio and ammonia amount as verified by the enhanced apatite-forming ability and antibacterial and non-hemolytic properties.
钙镁硅玻璃可用作硬组织再生支架的合成材料，因为它们具有高残余玻璃相、高硬度值和形成羟基磷灰石的能力。在人体中使用微量元素，如铜，可以提高这些玻璃的生物性能，因为铜在血管生成中起着重要的作用。与微尺度相比，纳米生物陶瓷更受欢迎，因为它们的比表面积更大，这不仅提高了机械性能和磷灰石形成能力，还因为增加了成核点，提高了扩散速率，减少了烧结时间或温度，并提高了机械性能。本工作的目的是评估不同乙醇/TEOS 比和总氨插入量对四元体系 SiO-CaO-MgO-CuO 中纳米颗粒粒径、形态和生物活性、溶血和抗菌行为的影响。不同的乙醇/TEOS 比和氨的量影响了生物活性纳米粉末的粒径和形态。通过增强的成磷灰石能力以及抗菌和非溶血特性来验证，具有最高乙醇/TEOS 比和氨量的材料是最佳的合成材料。
