Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China.
Chem Commun (Camb). 2019 Sep 10;55(73):10940-10943. doi: 10.1039/c9cc05624f.
Different from traditional "always on" photothermal therapy (PTT) agents, tumor microenvironment responsive agents showed more tumor specificity and lower photo-toxicity to normal tissues. Herein, a photo-stable and reversible pH responsive phenazine dye (PIOH) was synthesized and assembled with liposomes forming nanoparticles (PIOH-NPs), which exhibited a strong NIR absorption in a weak acid environment and were successfully utilized for photoacoustic (PA) imaging-guided photothermal therapy in mice.
与传统的“始终开启”光热治疗（PTT）剂不同，肿瘤微环境响应型试剂表现出更高的肿瘤特异性和更低的光毒性对正常组织。在此，合成了一种光稳定且可还原的 pH 响应吩嗪染料（PIOH），并将其与脂质体组装形成纳米颗粒（PIOH-NPs），在弱酸环境中具有很强的近红外吸收，并成功用于小鼠的光声（PA）成像引导光热治疗。
