Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea.
College of Science and Technology, Dankook University, Cheonan 31116, Korea.
Int J Mol Sci. 2022 Oct 6;23(19):11862. doi: 10.3390/ijms231911862.
Clay-based bio-inorganic nanohybrids, such as layered double hydroxides (LDH), have been extensively researched in the various fields of biomedicine, particularly for drug delivery and bio-imaging applications. Recent trends indicate that such two-dimensional LDH can be hybridized with a variety of photo-active biomolecules to selectively achieve anti-cancer benefits through numerous photo/chemotherapies (PCT), including photothermal therapy, photodynamic therapy, and magnetic hyperthermia, a combination of therapies to achieve the best treatment regimen for patients that cannot be treated either by surgery or radiation alone. Among the novel two-dimensional clay-based bio-inorganic nanohybrids, LDH could enhance the photo-stability and drug release controllability of the PCT agents, which would, in turn, improve the overall phototherapeutic performance. This review article highlights the most recent advances in LDH-based two-dimensional clay-bio-inorganic nanohybrids for the aforementioned applications.
黏土基生物无机纳米杂化材料，如层状双氢氧化物（LDH），在生物医学的各个领域都得到了广泛的研究，特别是在药物输送和生物成像应用方面。最近的趋势表明，这种二维 LDH 可以与多种光活性生物分子杂交，通过多种光/化疗（PCT）选择性地实现抗癌益处，包括光热疗法、光动力疗法和磁热疗，这些疗法的结合可以为那些不能单独通过手术或放疗治疗的患者制定最佳的治疗方案。在新型二维黏土基生物无机纳米杂化材料中，LDH 可以提高 PCT 试剂的光稳定性和药物释放可控性，从而提高整体光疗性能。本文综述了 LDH 为基础的二维黏土-生物无机纳米杂化材料在上述应用中的最新进展。
