Emerg Infect Dis. 2019 Sep;25(9):1683-9. doi: 10.3201/eid2509.181142.
To assess whether risk for Clostridiodes difficile infection (CDI) is higher among older adults with cancer, we conducted a retrospective cohort study with a nested case-control analysis using population-based Surveillance, Epidemiology, and End Results-Medicare linked data for 2011. Among 93,566 Medicare beneficiaries, incident CDI and odds for acquiring CDI were higher among patients with than without cancer. Specifically, risk was significantly higher for those who had liquid tumors and higher for those who had recently diagnosed solid tumors and distant metastasis. These findings were independent of prior healthcare-associated exposure. This population-based assessment can be used to identify targets for prevention of CDI.
为了评估癌症老年患者发生艰难梭菌感染（CDI）的风险是否更高，我们利用基于人群的监测、流行病学和最终结果-医疗保险链接数据进行了一项回顾性队列研究，并进行了嵌套病例对照分析，该研究的数据时间为 2011 年。在 93566 名医疗保险受益人中，患有 CDI 的患者和发生 CDI 的几率均高于未患有癌症的患者。具体而言，患有液体肿瘤的患者风险显著更高，而最近被诊断出患有实体肿瘤和远处转移的患者风险更高。这些发现与之前的医疗保健相关暴露无关。这种基于人群的评估可用于确定 CDI 预防的目标。
