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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Feitsma K G, Postma D S, Koëter G H, Nossent G D, Brenth B F, de Zeeuw R A

Department of Analytical Chemistry and Toxicology, Groningen, The Netherlands.

Br J Clin Pharmacol. 1988 Jun;25(6):683-7. doi: 10.1111/j.1365-2125.1988.tb05253.x.

Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo.

在一项四向双盲交叉研究中，八名患有慢性气流阻塞的成年患者吸入了消旋溴化羟苯乙铵、其对映体和安慰剂。2. 在吸入后的前6小时内测量一秒用力呼气容积（FEV1）和慢吸气肺活量（VC）。3. 发现（+）-羟苯乙铵是活性对映体（优映体），其支气管扩张作用优于（+/-）-羟苯乙铵。4. 非活性对映体（-）-羟苯乙铵与安慰剂相比，对FEV1和VC仅显示出轻微影响。

Feitsma K G, Postma D S, Koëter G H, Nossent G D, Brenth B F, de Zeeuw R A

Department of Analytical Chemistry and Toxicology, Groningen, The Netherlands.

Br J Clin Pharmacol. 1988 Jun;25(6):683-7. doi: 10.1111/j.1365-2125.1988.tb05253.x.

Racemic oxyphenonium bromide, its enantiomers and placebo were inhaled by eight adult patients with chronic airflow obstruction, in a four-way double-blind cross-over study. 2. Forced expiratory volume in one second (FEV1) and slow inspiratory vital capacity (VC) were measured during the first 6 h after inhalation. 3. (+)-Oxyphenonium was found to be the active enantiomer (eutomer), providing better bronchodilation than (+/-)-oxyphenonium. 4. The distomer, (-)-oxyphenonium, showed only a slight effect on FEV1 and VC as compared with placebo.

在一项四向双盲交叉研究中，八名患有慢性气流阻塞的成年患者吸入了消旋溴化羟苯乙铵、其对映体和安慰剂。2. 在吸入后的前6小时内测量一秒用力呼气容积（FEV1）和慢吸气肺活量（VC）。3. 发现（+）-羟苯乙铵是活性对映体（优映体），其支气管扩张作用优于（+/-）-羟苯乙铵。4. 非活性对映体（-）-羟苯乙铵与安慰剂相比，对FEV1和VC仅显示出轻微影响。