Koëter G H, Meurs H, Jonkman J H, Greving J, Leferink J, Sluiter H J, de Zeeuw R A, de Vries K
Eur J Clin Pharmacol. 1984;26(4):435-41. doi: 10.1007/BF00542137.
The protective effects of oxyphenonium bromide, terbutaline and theophylline were compared in 8 asthmatic patients by determination of the degree of non-specific airway reactivity after 1 week of oral treatment according to a fixed dose scheme in a double-blind random order: oxyphenonium bromide 3 X 10 mg; terbutaline 3 X 5 mg; theophylline 2 X 300 mg and placebo. Controlled, standardized inhalation provocation tests were carried out with histamine, acetylcholine and propranolol. The study was monitored by measuring blood concentrations of the 3 drugs, and their effect on the plasma cAMP concentration was also determined. Significant protection by oxyphenonium bromide against the bronchial obstructive effects of acetylcholine and propranolol was observed, but not against the effect of inhaled histamine. The other two drugs provided no significant protection against the inhaled agents. The absence of any protective effect of terbutaline and theophylline might have resulted from too low a blood concentration. The observed differences in protection could not be explained by changes in pulmonary function. The study suggests dissociation between the bronchodilating effect of a drug and its protective effect against inhaled substances.
在8名哮喘患者中，按照固定剂量方案，以双盲随机顺序口服治疗1周后，通过测定非特异性气道反应程度，比较了溴甲阿托品、特布他林和茶碱的保护作用：溴甲阿托品3×10毫克；特布他林3×5毫克；茶碱2×300毫克以及安慰剂。使用组胺、乙酰胆碱和普萘洛尔进行了对照、标准化的吸入激发试验。通过测量这3种药物的血药浓度对研究进行监测，并且还测定了它们对血浆环磷酸腺苷（cAMP）浓度的影响。观察到溴甲阿托品对乙酰胆碱和普萘洛尔的支气管阻塞作用有显著保护作用，但对吸入组胺的作用没有保护作用。另外两种药物对吸入剂没有显著保护作用。特布他林和茶碱没有任何保护作用可能是由于血药浓度过低所致。观察到的保护作用差异无法用肺功能变化来解释。该研究表明药物的支气管扩张作用与其对吸入物质的保护作用之间存在分离。
