Nutrient Metabolism & Signalling Laboratory, Department of Biochemistry and Molecular Biology, Metabolism, Diabetes and Obesity Program, Biomedicine Discovery Institute, Monash University, Clayton 3800, Australia.
Nutrients. 2019 Aug 23;11(9):1990. doi: 10.3390/nu11091990.
Dietary protein profoundly influences organismal traits ultimately affecting healthspan. While intracellular signalling downstream of altered amino acid supply is undoubtedly important, peptide hormones have emerged as critical factors determining systemic responses to variations in protein intake. Here the regulation and role of certain peptides hormones in such responses to altered dietary protein intake is reviewed.
饮食蛋白质对机体特征有深远影响,最终影响健康寿命。虽然氨基酸供应改变下游的细胞内信号传递无疑是重要的,但肽类激素已成为决定全身对蛋白质摄入变化反应的关键因素。本文综述了这些肽类激素在改变饮食蛋白质摄入的反应中的调节和作用。