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新辅助治疗的胃食管癌中感觉异常的一种罕见病因。

An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancer.

作者信息

Derby Sarah, Graham Janet, McIntosh David

机构信息

Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.

Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.

出版信息

BMJ Case Rep. 2019 Aug 22;12(8):e225450. doi: 10.1136/bcr-2018-225450.

Abstract

There is ongoing debate about the best neo-adjuvant strategy for localised resectable oesophageal cancer, however chemotherapy is often employed. Both oesophageal cancer and cisplatin carry an increased risk of thrombosis. Here, we look at an unusual finding in a previously fit woman who presented following neo-adjuvant chemotherapy for resectable oesophageal cancer with increasing difficulty in walking and lower limb paraesthesia. This case looks particularly at the diagnostic challenge and concerns raised in a patient undergoing radical treatment as well as the challenge of complications secondary to treatment with chemotherapy. Willingness to reassess and revisit is a vital part of the diagnostic process. Vascular complications of a disease can be notorious to diagnose and, as in this case can mimic arguably more logical diagnoses. Cancer care provides the unique challenge of investigating unusual presentations related both to disease and treatment.

摘要

关于局部可切除食管癌的最佳新辅助治疗策略一直存在争议,不过化疗经常被采用。食管癌和顺铂都有增加血栓形成的风险。在此,我们来看一位既往健康的女性患者的不寻常发现,她在接受新辅助化疗以治疗可切除食管癌后出现行走困难加重和下肢感觉异常。该病例特别关注了接受根治性治疗的患者所面临的诊断挑战和问题,以及化疗治疗引发的并发症挑战。愿意重新评估和审视是诊断过程的重要组成部分。疾病的血管并发症可能 notoriously(此处未明确具体含义,可能是“极其”之类的意思)难以诊断,就像这个病例一样,可能会模拟出看似更合理的诊断。癌症治疗带来了调查与疾病和治疗相关的异常表现的独特挑战。

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本文引用的文献

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Obesity, Thrombotic Risk, and Inflammation in Cancer.肥胖、血栓形成风险与癌症炎症
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