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BMJ Case Rep. 2019 Aug 22;12(8):e225450. doi: 10.1136/bcr-2018-225450.
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Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial.氟尿嘧啶+亚叶酸、奥沙利铂和多西紫杉醇与氟尿嘧啶或卡培他滨+顺铂和表柔比星用于局部晚期可切除胃或胃食管交界处腺癌的围手术期化疗(FLOT4):一项随机、2/3 期试验。
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Aortic Mural Thrombus in the Non-atherosclerotic Aorta of Patients with Multiple Hypercoagulable Factors.具有多种高凝因素患者的非动脉粥样硬化性主动脉壁内血栓形成
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Obesity, Thrombotic Risk, and Inflammation in Cancer.肥胖、血栓形成风险与癌症炎症
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Apixaban and dalteparin in active malignancy associated venous thromboembolism. The ADAM VTE Trial.阿哌沙班和达肝素治疗活动性恶性肿瘤相关静脉血栓栓塞症。ADAM VTE 试验。
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Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial.新辅助多西他赛、奥沙利铂、氟尿嘧啶和亚叶酸钙与表柔比星、顺铂和氟尿嘧啶或卡培他滨用于可切除胃或胃食管交界处腺癌患者(FLOT4-AIO):多中心、开放标签、随机 2/3 期临床试验 2 期部分的结果。
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Risk of Vascular Toxicity with Platinum Based Chemotherapy in Elderly Patients with Bladder Cancer.老年膀胱癌患者接受铂类化疗时发生血管毒性的风险
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Acute aortic thrombosis in patients receiving cisplatin-based chemotherapy.接受顺铂为基础的化疗的患者的急性主动脉血栓。
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新辅助治疗的胃食管癌中感觉异常的一种罕见病因。

An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancer.

作者信息

Derby Sarah, Graham Janet, McIntosh David

机构信息

Clinical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.

Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK.

出版信息

BMJ Case Rep. 2019 Aug 22;12(8):e225450. doi: 10.1136/bcr-2018-225450.

DOI:10.1136/bcr-2018-225450
PMID:31444258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6721004/
Abstract

There is ongoing debate about the best neo-adjuvant strategy for localised resectable oesophageal cancer, however chemotherapy is often employed. Both oesophageal cancer and cisplatin carry an increased risk of thrombosis. Here, we look at an unusual finding in a previously fit woman who presented following neo-adjuvant chemotherapy for resectable oesophageal cancer with increasing difficulty in walking and lower limb paraesthesia. This case looks particularly at the diagnostic challenge and concerns raised in a patient undergoing radical treatment as well as the challenge of complications secondary to treatment with chemotherapy. Willingness to reassess and revisit is a vital part of the diagnostic process. Vascular complications of a disease can be notorious to diagnose and, as in this case can mimic arguably more logical diagnoses. Cancer care provides the unique challenge of investigating unusual presentations related both to disease and treatment.

摘要

关于局部可切除食管癌的最佳新辅助治疗策略一直存在争议,不过化疗经常被采用。食管癌和顺铂都有增加血栓形成的风险。在此,我们来看一位既往健康的女性患者的不寻常发现,她在接受新辅助化疗以治疗可切除食管癌后出现行走困难加重和下肢感觉异常。该病例特别关注了接受根治性治疗的患者所面临的诊断挑战和问题,以及化疗治疗引发的并发症挑战。愿意重新评估和审视是诊断过程的重要组成部分。疾病的血管并发症可能 notoriously(此处未明确具体含义,可能是“极其”之类的意思)难以诊断,就像这个病例一样,可能会模拟出看似更合理的诊断。癌症治疗带来了调查与疾病和治疗相关的异常表现的独特挑战。