微环境与交界性肿瘤发生中的谱系复杂性相遇。
Microenvironment meets lineage complexity in junctional tumorigenesis.
机构信息
Institute of Molecular Medicine, McGovern Medical School of The University of Texas Health Science Center, Houston, TX, 77030, USA.
Department of Biochemistry and Molecular Biology, University of Texas McGovern Medical School, Houston, TX, 77030, USA.
出版信息
Nat Commun. 2019 Aug 23;10(1):3829. doi: 10.1038/s41467-019-11651-6.
Abstract
Using a sensitizing genetic model, Moon and colleagues provide compelling data for a determinant role of microenvironment in tumorigenesis, and lend support to the notion that such influences can be pharmacologically dampened to reduce the onset of cancers.
摘要
利用一种敏化遗传模型，Moon 及其同事提供了令人信服的数据，证明了微环境在肿瘤发生中的决定性作用，并支持这样一种观点，即可以通过药理学手段抑制这种影响，从而降低癌症的发病风险。
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