肿瘤微环境中的免疫细胞代谢。

Immune Cell Metabolism in Tumor Microenvironment.

机构信息

Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

出版信息

Adv Exp Med Biol. 2017;1011:163-196. doi: 10.1007/978-94-024-1170-6_5.

DOI:10.1007/978-94-024-1170-6_5

PMID:28875490

Abstract

Tumor microenvironment (TME) is composed of tumor cells, immune cells, cytokines, extracellular matrix, etc. The immune system and the metabolisms of glucose, lipids, amino acids, and nucleotides are integrated in the tumorigenesis and development. Cancer cells and immune cells show metabolic reprogramming in the TME, which intimately links immune cell functions and edits tumor immunology. Recent findings in immune cell metabolism hold the promising possibilities toward clinical therapeutics for treating cancer. This chapter introduces the updated understandings of metabolic reprogramming of immune cells in the TME and suggests new directions in manipulation of immune responses for cancer diagnosis and therapy.

摘要

肿瘤微环境（TME）由肿瘤细胞、免疫细胞、细胞因子、细胞外基质等组成。免疫系统和葡萄糖、脂质、氨基酸和核苷酸的代谢在肿瘤的发生和发展中是整合在一起的。在肿瘤微环境中，癌细胞和免疫细胞表现出代谢重编程，这与免疫细胞功能密切相关，并编辑了肿瘤免疫学。免疫细胞代谢的最新发现为癌症的临床治疗提供了有希望的可能性。本章介绍了免疫细胞在肿瘤微环境中代谢重编程的最新认识，并为癌症诊断和治疗中免疫反应的调控提出了新的方向。