Jarienė Kristina, Drejerienė Eglė, Jaras Algirdas, Kabašinskienė Austė, Čelkienė Ieva, Urbonavičienė Neringa
Obstetrics and Gynecology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Obstetrics and Gynecology Department, Lithuanian University of Health Sciences, Kaunas, Lithuania.
J Pediatr Adolesc Gynecol. 2019 Dec;32(6):574-578. doi: 10.1016/j.jpag.2019.08.009. Epub 2019 Aug 21.
To evaluate genital microbiological findings in prepubertal girls with vulvovaginitis and in healthy controls.
Prospective case-control study.
Pediatric Outpatient unit of the Department of Pediatrics of the Hospital of the Lithuanian University of Health Sciences Kauno Klinikos from November 2014 to May 2017.
Fifty-two prepubertal girls aged 1-9 years diagnosed with vulvovaginitis, and 42 age-matched healthy controls.
Samples for microbiological culture were collected using sterile cotton swabs from the introitus and the lower third of the vagina from all study participants. Microbiological findings were analyzed according to bacteria type and intensity of growth.
Most of the vaginal microbiological swab results were positive for bacterial growth: 47 (90.4%) and 34 (80.9%) were similar in the study and control groups, respectively (P = .24). Sixteen (30.8%) and 9 (21.4%) of the microbiological traits results in the case and control groups, respectively, were regarded as potential causative agents (P = .27). Streptococcus pyogenes was the most frequent pathogen in the study group (P = .03); all other microorganisms detected as either a pure or dominant growth in the control group, were considered opportunistic.
Vaginal bacterial culture results were positive in prepubertal girls with vulvovaginitis and in healthy controls. Nonspecific vulvovaginitis without a dominant/isolated pathogen was seen to be more common than vulvovaginitis with a potential causative agent. Clinical symptoms were more frequent among girls when the potential infectious agent was identified.
评估青春期前患外阴阴道炎女童及健康对照者的生殖道微生物学检查结果。
前瞻性病例对照研究。
2014年11月至2017年5月，立陶宛卫生科学大学考纳斯临床医院儿科门诊。
52名年龄在1 - 9岁、诊断为外阴阴道炎的青春期前女童，以及42名年龄匹配的健康对照者。
使用无菌棉拭子从所有研究参与者的阴道口及阴道下三分之一处采集微生物培养样本。根据细菌类型和生长强度分析微生物学检查结果。
大多数阴道微生物拭子检查结果显示细菌生长呈阳性：研究组47例（90.4%），对照组34例（80.9%），二者相似（P = 0.24）。病例组和对照组分别有16例（30.8%）和9例（21.4%）的微生物特征结果被视为潜在病原体（P = 0.27）。化脓性链球菌是研究组中最常见的病原体（P = 0.03）；在对照组中检测到的所有其他以纯培养或优势生长形式存在的微生物，均被视为机会性致病菌。
青春期前患外阴阴道炎女童及健康对照者的阴道细菌培养结果均为阳性。无优势/单一病原体的非特异性外阴阴道炎比有潜在病原体的外阴阴道炎更为常见。当识别出潜在感染病原体时，女童出现临床症状更为频繁。
