氟罗沙星与氧氟沙星在实验性肾盂肾炎中的对比研究。
Comparative studies of fleroxacin and ofloxacin in experimental pyelonephritis.
作者信息
Ritzerfeld W
机构信息
Institute of Medical Microbiology WWU, Muenster, West Germany.
出版信息
J Antimicrob Chemother. 1988 Oct;22 Suppl D:119-22. doi: 10.1093/jac/22.supplement_d.119.
Abstract
Two quinolones, fleroxacin and ofloxacin were used as oral treatment in a model of experimental pyelonephritis in rats. The infecting strains were Escherichia coli, Klebsiella oxytoca and Pseudomonas aeruginosa. Compared to untreated control rats, the rats treated with the quinolones showed a great reduction in bacterial counts in kidney tissue and urine. At lower dosages, fleroxacin had a greater bacterial killing effect than ofloxacin.
摘要
在大鼠实验性肾盂肾炎模型中，使用了两种喹诺酮类药物，即氟罗沙星和氧氟沙星进行口服治疗。感染菌株为大肠杆菌、产酸克雷伯菌和铜绿假单胞菌。与未治疗的对照大鼠相比，用喹诺酮类药物治疗的大鼠肾组织和尿液中的细菌数量大幅减少。在较低剂量下，氟罗沙星比氧氟沙星具有更强的杀菌效果。
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