Boyd N M, Reade P C
Department of Oral Biology, University of Otago, Dunedin, New Zealand.
J Oral Pathol. 1988 Jul;17(6):257-65. doi: 10.1111/j.1600-0714.1988.tb01534.x.
A number of changes occur in preneoplastic and neoplastic cells as they progress towards a greater degree of malignancy. These alterations include genetic changes, epigenetic changes, surface alterations and alterations in intercellular interactions. In some instances, these changes are contributing factors to the degree of pathology noted, whilst other are resultant. In many situations, the relationship between these changes and the progression towards neoplasia is not understood. Nevertheless, it seems probable that these changes are ultimately involved in driving cells further along the path to neoplastic transformation. It is the purpose of this review to consider the changes which occur as cells progress from normality to being neoplastic, with particular reference to the cells of the oral mucosa, and the use to which detectable changes can be used as prognostic indicators.
在癌前细胞和肿瘤细胞向更高程度恶性发展的过程中会发生许多变化。这些改变包括基因变化、表观遗传变化、表面改变以及细胞间相互作用的改变。在某些情况下，这些变化是所观察到的病理程度的促成因素，而其他变化则是结果。在许多情况下，这些变化与肿瘤形成进展之间的关系尚不清楚。然而，这些变化似乎最终参与推动细胞进一步沿着肿瘤转化的路径发展。本综述的目的是考虑细胞从正常状态发展为肿瘤状态时发生的变化，特别提及口腔黏膜细胞，以及可检测到的变化用作预后指标的用途。
