Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China.
Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, China; Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510120, China.
Int Immunopharmacol. 2019 Oct;75:105817. doi: 10.1016/j.intimp.2019.105817. Epub 2019 Aug 23.
Artesunate (ART), a derivative of artemisinin, is a medication to treat malaria. Beyond that, the anti-inflammatory and immunoregulatory activities of ART have been identified in autoimmune diseases. However, whether ART functions in psoriasis-like dermatitis induced by imiquimod (IMQ, a TLR7/8 agonist) is currently unkown. There, we found that the cumulative score, epidermal thickening and expression of Ki-67 of ART-treated BALB/c mice were significantly lower than those in the IMQ psoriatic model group. In addition, ART treatment ameliorated mice from systemic inflammation. Mechanistically, ART reduced γδ T cells in draining lymph nodes, which might be benefit the improvement of dermatitis. These findings suggested that ART could be a promising drug of psoriasis in clinic.
青蒿琥酯（ART）是青蒿素的衍生物，是一种治疗疟疾的药物。除此之外，ART 的抗炎和免疫调节作用已在自身免疫性疾病中得到证实。然而，ART 是否对咪喹莫特（IMQ，TLR7/8 激动剂）诱导的银屑病样皮炎起作用目前尚不清楚。在那里，我们发现青蒿琥酯治疗的 BALB/c 小鼠的累积评分、表皮增厚和 Ki-67 的表达明显低于咪喹莫特银屑病模型组。此外，ART 治疗改善了全身炎症的小鼠。从机制上讲，ART 减少引流淋巴结中的 γδ T 细胞，这可能有益于皮炎的改善。这些发现表明，ART 可能是一种有前途的银屑病临床药物。
