青蒿素及其衍生物有望成为自身免疫性疾病的治疗方法。
Artemisinin and its derivatives as promising therapies for autoimmune diseases.
作者信息
Xie Kaidi, Li Zhen, Zhang Yang, Wu Hao, Zhang Tong, Wang Wen
机构信息
Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, 100069, China.
Beijing Key Laboratory for HIV/ AIDS Research, Beijing, 100069, China.
出版信息
Heliyon. 2024 Mar 11;10(7):e27972. doi: 10.1016/j.heliyon.2024.e27972. eCollection 2024 Apr 15.
Abstract
Artemisinin, a traditional Chinese medicine with remarkable antimalarial activity. In recent years, studies demonstrated that artemisinin and its derivatives (ARTs) showed anti-inflammatory and immunoregulatory effects. ARTs have been developed and gradually applied to treat autoimmune and inflammatory diseases. However, their role in the treament of patients with autoimmune and inflammatory diseases in particular is less well recognized. This review will briefly describe the history of ARTs use in patients with autoimmune and inflammatory diseases, the theorized mechanisms of action of the agents ARTs, their efficacy in patients with autoinmmune and inflammatory diseases. Overall, ARTs have numerous beneficial effects in patients with autoimmune and inflammatory diseases, and have a good safety profile.
摘要
青蒿素是一种具有显著抗疟活性的传统中药。近年来，研究表明青蒿素及其衍生物（ARTs）具有抗炎和免疫调节作用。ARTs已被研发并逐渐应用于治疗自身免疫性疾病和炎症性疾病。然而，它们在治疗自身免疫性疾病和炎症性疾病患者中的具体作用尚鲜为人知。本综述将简要描述ARTs在自身免疫性疾病和炎症性疾病患者中的应用历史、其作用机制的理论推测、它们在自身免疫性疾病和炎症性疾病患者中的疗效。总体而言，ARTs对自身免疫性疾病和炎症性疾病患者有诸多有益作用，且安全性良好。
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