苯巴比妥对血清高密度脂蛋白亚组分及载脂蛋白的影响。
The effects of phenobarbital on serum high density lipoprotein subfractions and apolipoproteins.
作者信息
Luoma P V, Marniemi J, Sotaniemi E A
机构信息
Department of Medicine, University of Oulu, Finland.
出版信息
Res Commun Chem Pathol Pharmacol. 1988 Oct;62(1):125-8.
Prospective studies report that a pharmacologic elevation of serum high density lipoprotein (HDL) concentration may be of value in the prevention of atherosclerosis. In this study phenobarbital, 50 mg at bedtime for ten days, increased serum HDL cholesterol, HDL2 cholesterol and HDL cholesterol/cholesterol and HDL cholesterol/apolipoprotein A-I ratios. Phenobarbital treated subjects had serum lipoprotein profile typical of low risk of ischemic heart disease.
前瞻性研究报告称，血清高密度脂蛋白（HDL）浓度的药物性升高可能对预防动脉粥样硬化有价值。在本研究中，每晚睡前服用50毫克苯巴比妥，持续十天，可提高血清HDL胆固醇、HDL2胆固醇以及HDL胆固醇/胆固醇和HDL胆固醇/载脂蛋白A-I的比值。接受苯巴比妥治疗的受试者具有缺血性心脏病低风险典型的血清脂蛋白谱。
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