Luoma P V, Rautio A, Stengård J, Sotaniemi E A, Marniemi J
Department of Medicine, University of Oulu, Finland.
Eur J Clin Pharmacol. 1990;38(6):625-7. doi: 10.1007/BF00278594.
Serum high density lipoprotein (HDL) subfractions HDL2 and HDL3, apolipoproteins, and plasma antipyrine clearance (AP-CL) rate, an index of liver microsomal enzyme activity, were determined in 21 healthy subjects. High HDL cholesterol and HDL2 cholesterol concentrations and HDL cholesterol/cholesterol and HDL2/HDL3 cholesterol ratios were associated with high AP-CL. Phenobarbital enhanced antipyrine elimination and increased the apolipoprotein A-I/A-II ratio. Subjects who had high AP-CL had a more antiatherogenic HDL subfraction and apolipoprotein profile than those with low AP-CL.
在21名健康受试者中测定了血清高密度脂蛋白（HDL）亚组分HDL2和HDL3、载脂蛋白以及血浆安替比林清除率（AP-CL）（肝脏微粒体酶活性指标）。高HDL胆固醇和HDL2胆固醇浓度以及HDL胆固醇/胆固醇和HDL2/HDL3胆固醇比值与高AP-CL相关。苯巴比妥可增强安替比林消除并提高载脂蛋白A-I/A-II比值。与低AP-CL的受试者相比，高AP-CL的受试者具有更具抗动脉粥样硬化作用的HDL亚组分和载脂蛋白谱。
