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Lipoproteins and apolipoproteins in postmortem serum.

作者信息

Hornick C A, Baker H N, Malcom G T, Newman W P, Roheim P S, Strong J P

机构信息

Department of Physiology, Louisiana State University Medical Center, New Orleans.

出版信息

Mod Pathol. 1988 Nov;1(6):480-4.

PMID:3146754
Abstract

In order to correlate lipoprotein and apolipoprotein profiles with atherosclerotic lesions at autopsy, the feasibility of using postmortem serum in these determinations was evaluated. Lipoprotein and apolipoprotein profiles in dogs and monkeys were compared in pre- and postmortem serum samples, and it was found that, up to 24 h postmortem, no appreciable differences were observed in apolipoprotein A-I, B, E, and A-IV serum concentration when compared to premortem values. Electrophoretic mobilities and apolipoprotein gradient gel immunoblotting also revealed no differences in apolipoprotein size distribution. We conclude that postmortem sampling up to 24 h can be used effectively to approximate premortem lipoprotein and apolipoprotein profiles provided that careful sampling techniques are observed.

摘要

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