Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, 242, Taiwan; Department of Environmental Engineering and Health, Yuanpei University of Medical Technology, Hsinchu 300, Taiwan.
National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Int J Hyg Environ Health. 2020 Jan;223(1):248-255. doi: 10.1016/j.ijheh.2019.08.005. Epub 2019 Aug 22.
Environmental lead exposure is a known risk factor of cardiovascular disease (CVD) in animal and human epidemiological studies of adults, but limited research has been conducted in young populations. Moreover, the association between lead level and common carotid artery intima-media thickness (CIMT) has never been documented.
and Participants: In this study, 738 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between lead levels in urine and CVD risk factors, metabolic syndrome (MS) and CIMT.
The geometric mean of the urine lead level was 1.50 μg/g creatinine. We found a significant positive association between urine lead levels and CVD risk factors, including diastolic blood pressure (DBP), mean arterial pressure (MAP), as well as markers of glucose homeostasis, such as serum glucose, serum insulin, homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), body mass index (BMI) z score, and CIMT. Overall, increased urine lead concentrations were positively correlated with the prevalence of MS, specifically the criteria of waist/BMI and serum HDL-C. The relationship between urine lead levels and CIMT remained unchanged in all subgroups.
In this study, we found that increased urinary levels of lead were positively associated with CVD risk factors, CIMT, and MS in this cohort. Future research to explore the pathogenic basis of exposure to lead and risk of CVDs and their risk factors are warranted.
在动物和成人流行病学研究中，环境铅暴露是心血管疾病 (CVD) 的已知危险因素，但在年轻人群中的研究有限。此外，铅水平与颈总动脉内膜-中层厚度 (CIMT) 之间的关联从未有过记录。
在这项研究中，从台湾青少年和年轻成年人队列中招募了 738 名受试者，以研究尿液中的铅水平与 CVD 危险因素、代谢综合征 (MS) 和 CIMT 之间的关系。
尿液中铅水平的几何平均值为 1.50μg/g 肌酐。我们发现尿液铅水平与 CVD 危险因素之间存在显著正相关，包括舒张压 (DBP)、平均动脉压 (MAP) 以及葡萄糖稳态标志物，如血清葡萄糖、血清胰岛素、胰岛素抵抗的稳态模型评估 (HOMA-IR) 、β细胞功能的稳态模型评估 (HOMA-β)、体重指数 (BMI) z 评分和 CIMT。总体而言，尿液铅浓度的升高与 MS 的患病率呈正相关，特别是腰围/BMI 和血清 HDL-C 的标准。尿液铅水平与 CIMT 之间的关系在所有亚组中均保持不变。
在这项研究中，我们发现该队列中尿液中铅水平的升高与 CVD 危险因素、CIMT 和 MS 呈正相关。需要进一步研究探索接触铅与 CVD 及其危险因素之间的发病基础。
