Department of Internal Medicine, En Chu Kong Hospital, New Taipei City, 237, Taiwan; School of Medicine, Fu Jen Catholic University, New Taipei City, 242, Taiwan.
Department of Statistics, National Taipei University, New Taipei City, 237, Taiwan.
Environ Pollut. 2019 Mar;246:107-113. doi: 10.1016/j.envpol.2018.11.110. Epub 2018 Dec 1.
In the family of alkylphenolic compounds, 4-tertiary-Octylphenol (4-t-OP) is extensively used in many products. In animal and in vitro studies, 4-t-OP exposure has been linked to cardiovascular disease (CVD) risk factors; however, there are no previous human epidemiological studies. In this study, 886 subjects were recruited from a cohort of Taiwanese adolescents and young adults to study the relationship between serum levels of 4-t-OP, CVD risk factors, and common carotid artery intima-media thickness (CIMT). The geometric mean (SD) 4-t-OP concentration was 32.52 (1.71) ng/mL. We found that serum levels of 4-t-OP were negatively associated with markers of glucose homeostasis (insulin, homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β)), z score of body mass index (BMI z score) and CIMT but were positively associated with lipid profiles (high density lipoprotein cholesterol (HDL-C), Apolipoprotein A1). A one-unit elevation in natural log-transformed 4-t-OP (ng/mL) was negatively correlated with CIMT (mm) (β = -0.029, SE = 0.003, P < 0.001) in multiple linear regression analyses. The relationship between 4-t-OP and CIMT remained the same in all subgroups or if bisphenol A (BPA) was considered a covariate. In this study, we observed that higher levels of 4-t-OP levels were negatively correlated with markers of glucose homeostasis, BMI z score, and CIMT; positively correlated with lipid profiles (HDL-C and apolipoprotein A) in this cohort. Future research on exposure to 4-t-OP and CVD risk factors is warranted.
在烷基酚化合物家族中，4-叔辛基苯酚（4-t-OP）广泛应用于许多产品中。在动物和体外研究中，4-t-OP 暴露与心血管疾病（CVD）风险因素有关；然而，以前没有人类流行病学研究。在这项研究中，从台湾青少年和年轻人队列中招募了 886 名受试者，以研究血清 4-t-OP 水平、CVD 风险因素和颈总动脉内膜中层厚度（CIMT）之间的关系。几何平均值（标准差）4-t-OP 浓度为 32.52（1.71）ng/mL。我们发现，血清 4-t-OP 水平与葡萄糖稳态标志物（胰岛素、胰岛素抵抗评估的稳态模型（HOMA-IR）和β细胞功能的稳态模型评估（HOMA-β））、体重指数（BMI）z 评分和 CIMT 呈负相关，但与血脂谱（高密度脂蛋白胆固醇（HDL-C）、载脂蛋白 A1）呈正相关。自然对数转换后 4-t-OP （ng/mL）每增加一个单位，与多元线性回归分析中的 CIMT （mm）呈负相关（β= -0.029，SE = 0.003，P < 0.001）。在所有亚组或考虑双酚 A（BPA）为协变量的情况下，4-t-OP 与 CIMT 之间的关系保持不变。在这项研究中，我们观察到，在该队列中，较高水平的 4-t-OP 水平与葡萄糖稳态标志物、BMI z 评分和 CIMT 呈负相关，与血脂谱（HDL-C 和载脂蛋白 A）呈正相关。有必要对 4-t-OP 暴露与 CVD 风险因素进行进一步研究。
