免疫细胞在类天疱疮疾病眼部表现中的作用。
Role of immune cells in the ocular manifestations of pemphigoid diseases.
作者信息
Bose Tanima
机构信息
Institute for Clinical Neuroimmunology, Biomedicine Zentrum, Ludwig Maximilian University of Munich, Grosshaderner Strasse 9, 82152 Planegg-Martinsried, Munich, Germany.
出版信息
Ther Adv Ophthalmol. 2019 Aug 8;11:2515841419868128. doi: 10.1177/2515841419868128. eCollection 2019 Jan-Dec.
Pemphigoid disease is classified according to the phenotypical location of the disease and the presence of different types of antibodies. The ocular distribution of pemphigoid mainly occurs in patients with bullous pemphigoid and mucous membrane pemphigoid. Several immune cells, including the cells of the innate immune system (neutrophils and γδ T cells) and the adaptive immune system (T and B cells), are involved in pemphigoid disease. The treatment of pemphigoid is still wide-ranging, and the most utilized treatment is the use of immunosuppressants and corticosteroids. In this scenario, it is absolutely important to screen the immune cells that are involved in this group of diseases and to determine if a targeted treatment approach is plausible. In conclusion, this review will identify some newer treatment possibilities for the whole spectrum of pemphigoid diseases.
类天疱疮疾病根据疾病的表型定位和不同类型抗体的存在进行分类。类天疱疮的眼部分布主要发生在大疱性类天疱疮和黏膜类天疱疮患者中。几种免疫细胞，包括先天免疫系统的细胞（中性粒细胞和γδ T细胞）和适应性免疫系统的细胞（T细胞和B细胞），都参与了类天疱疮疾病。类天疱疮的治疗方法仍然多种多样，最常用的治疗方法是使用免疫抑制剂和皮质类固醇。在这种情况下，筛查参与这组疾病的免疫细胞并确定靶向治疗方法是否可行绝对重要。总之，本综述将确定类天疱疮疾病全谱的一些新的治疗可能性。
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