Department of Physics and Astronomy, VU University, HV Amsterdam, The Netherlands.
Department of Ophthalmology, Amsterdam UMC, location VUMC, HV Amsterdam, The Netherlands.
Acta Ophthalmol. 2020 Mar;98(2):158-165. doi: 10.1111/aos.14214. Epub 2019 Aug 26.
To illustrate Optical Coherence Tomography (OCT) images of active and inactive retinoblastoma (Rb) tumours.
Current observational study included patients diagnosed with retinoblastoma and retinoma who were presented at Amsterdam UMC and Jules-Gonin Eye Hospital, between November 2010 and October 2017. Patients aged between 0 and 4 years were imaged under general anaesthesia with handheld OCT in supine position. Patients older than 4 years were imaged with the conventional OCT (Heidelberg Engineering, Heidelberg Spectralis, Germany). All patients included were divided into two groups: active and inactive tumours (retinoma and regression patterns). Patients' medical records and OCT images were analysed during meetings via discussions by ophthalmologists and physicists.
Twelve Dutch and 8 Swiss patients were divided into two groups: 2 patients with active tumour versus 18 patients with inactive tumour. Subsequently, inactive group could be divided in two groups, which consisted of 10 patients with retinoma and 8 patients with different regression pattern types. Of all included patients, 15 were male (75%). Median age at diagnosis was 18.0 months (range 0.19-715.2 months). A total of 12 retinoblastoma (active and inactive) and 8 retinoma foci were investigated by OCT. No distinction could be made between active and inactive tumours using only OCT.
Optical coherence tomography alone cannot distinguish between active and inactive Rbs. However, handheld OCT adds useful information to the established imaging techniques in the monitoring and follow-up of retinoblastoma patients. With this study, we provide an overview of OCT images of active and inactive Rbs.
展示活性和非活性视网膜母细胞瘤（Rb）肿瘤的光相干断层扫描（OCT）图像。
本研究为当前观察性研究，纳入 2010 年 11 月至 2017 年 10 月期间在阿姆斯特丹 UMC 和朱尔斯·戈宁眼科医院就诊的诊断为视网膜母细胞瘤和视网膜细胞瘤的患者。0 至 4 岁的患者在全身麻醉下仰卧位接受手持 OCT 成像，4 岁以上的患者接受常规 OCT（德国海德堡工程公司的 Heidelberg Spectralis）成像。所有纳入的患者均分为两组：活性和非活性肿瘤（视网膜细胞瘤和消退模式）。通过眼科医生和物理学家的讨论，在会议期间对患者的病历和 OCT 图像进行分析。
12 名荷兰患者和 8 名瑞士患者分为两组：2 名活性肿瘤患者与 18 名非活性肿瘤患者。随后，非活性肿瘤组可分为两组，一组由 10 名视网膜细胞瘤患者和 8 名不同消退模式类型的患者组成。所有纳入的患者中，男性 15 例（75%）。诊断时的中位年龄为 18.0 个月（范围 0.19-715.2 个月）。共对 12 个视网膜母细胞瘤（活性和非活性）和 8 个视网膜细胞瘤病灶进行了 OCT 检查。仅使用 OCT 无法区分活性和非活性 Rb 肿瘤。
单独的光相干断层扫描不能区分活性和非活性的 Rb 肿瘤。然而，手持 OCT 在监测和随访视网膜母细胞瘤患者时为现有的成像技术提供了有用的信息。通过本研究，我们提供了活性和非活性 Rb 的 OCT 图像概述。
