Fillette F, Nassif G, Aouate P
Laboratoire d'électrophysiologie, service de cardiologie, hôpital de la Salpêtrière, Paris, France.
Arch Mal Coeur Vaiss. 1988 Jun;81(6):801-7.
Intracellular microelectrodes were used to study the electrophysiological effects on action and resting potentials, refractory periods and conduction velocities of four contrast media administered either as 1/100 and 1/1000 solutions or as 20 mg bolus injections. The products studied were Telebrix, which has high osmolality (2100 mOsm/kg) and three other contrast media with lower osmolatity (700 mOsm/kg), including Hexabrix, which contains sodium, and Iopamidol and Iohexol which are sodium-free. The parameters measured were not modified by Hexabrix and Telebrix, whereas Omnipaque and Iopamiron induced varied and significant changes in these parameters, notably in concentrations of 1/100 and as bolus injections. It is suggested that the latter contrast media should be used in non-cardiovascular explorations and in patients without confirmed heart disease.
使用细胞内微电极研究了四种造影剂对动作电位、静息电位、不应期和传导速度的电生理影响，这些造影剂分别以1/100和1/1000溶液或20mg推注的形式给药。所研究的产品包括高渗的Telebrix（2100mOsm/kg）以及另外三种低渗造影剂（700mOsm/kg），其中包括含钠的Hexabrix，以及不含钠的碘帕醇和碘海醇。Hexabrix和Telebrix未改变所测量的参数，而欧乃派克和碘必乐在这些参数上引起了不同程度的显著变化，尤其是在1/100浓度和推注给药时。建议后两种造影剂应用于非心血管检查以及未确诊心脏病的患者。
