Suzuki K, Baba S, Inagaki M, Kobayashi T
Department of Otorhinolaryngology, Nagoya City University, School of Medicine.
Auris Nasus Larynx. 1988;15(2):105-11. doi: 10.1016/s0385-8146(88)80015-4.
Branhamella catarrhalis has been misconsidered as a normal resident in human respiratory tract for a long time. However, many authors recently have reported its pathogenecity and isolated it from the otolaryngological region. In our study, this organism can be isolated from the ear and nasal discharge in the child with acute otitis media by the rate of 7.5% and 21.4% respectively. Out of this 107 isolated strains, 97 strains (90.7%) were found to be beta-lactamase producing organisms. The MIC measurement of penicillins and cephems (except CEX) for inhibition of all these strains in our study is 6.25 micrograms/ml or less and because of the unreliability of the ABPC's susceptibility test by disk method, it is necessary to check the beta-lactamase production in each strain. Becoming of the high emergence rate of beta-lactamase producing strains, B. catarrhalis should be considered to be as important pathogen as Streptococcus pneumoniae and Haemophilus influenzae in upper respiratory tract infections in children.
卡他布兰汉菌长期以来一直被误认为是人类呼吸道的正常定植菌。然而，最近许多作者报道了它的致病性，并从耳鼻喉科区域分离出该菌。在我们的研究中，这种菌可分别从患有急性中耳炎儿童的耳分泌物和鼻分泌物中以7.5%和21.4%的比例分离出来。在这107株分离菌株中，发现97株（90.7%）为产β-内酰胺酶的菌株。在我们的研究中，青霉素和头孢菌素（除头孢克肟外）抑制所有这些菌株的最低抑菌浓度测定值为6.25微克/毫升或更低，并且由于用纸片法检测氨苄青霉素敏感性试验不可靠，有必要检测每株菌株的β-内酰胺酶产生情况。鉴于产β-内酰胺酶菌株的高出现率，在儿童上呼吸道感染中，卡他布兰汉菌应被视为与肺炎链球菌和流感嗜血杆菌同等重要的病原体。
