Okuda C, Mizobe T, Miyazaki M
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Japan.
Brain Res. 1988 Dec 6;474(2):399-402. doi: 10.1016/0006-8993(88)90459-3.
The 4th ventricle of a conscious rat was perfused using a push-pull cannula. The concentration of thyrotropin-releasing hormone (TRH) in the perfusate was significantly increased after withdrawal of 30% of the total blood. Administration of antiserum of TRH into the ventricle potentiated and prolonged the hypotension induced by the bleeding. These results suggest that endogenous brain TRH is involved in the central regulation of the cardiovascular system after bleeding in conscious rats.
使用推挽式套管对清醒大鼠的第四脑室进行灌注。在抽取总血量的30%后，灌注液中促甲状腺激素释放激素（TRH）的浓度显著升高。向脑室内注射TRH抗血清可增强并延长出血诱导的低血压。这些结果表明，内源性脑TRH参与清醒大鼠出血后心血管系统的中枢调节。
