Department of Chest Diseases, Occupational and Environmental Diseases Hospital, Ankara, Turkey.
Department of Pharmacology, Occupational and Environmental Diseases Hospital, Ankara, Turkey.
Hum Exp Toxicol. 2019 Nov;38(11):1227-1234. doi: 10.1177/0960327119871093. Epub 2019 Aug 26.
Welders' lung disease refers to mixed exposure to different kinds of metals and chemicals from welding fumes, which affect all parts of the respiratory tract including airways and parenchyma together. This study aimed to investigate the oxidative status in patients with welders' lung (PWL) by means of thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels. The male welder workers diagnosed with welders' lung disease and healthy individuals were recruited in the study. Plasma levels of disulfide, disulfide/native thiol ratio, disulfide/total thiol ratio, IMA, and catalase (CAT) were determined. Pulmonary function test parameters of both groups were compared. The thiol-disulfide homeostasis parameters of PWL and control group were as follows: disulfide (20.5 ± 6.3 vs. 16.2 ± 3.9 μmol L, < 0.001), disulfide/native thiol (4.36 (1.59) vs. 4.0 (1.64), = 0.024), and disulfide/total thiol (4.01 (1.34) vs. 3.71 (1.41), = 0.024). IMA levels in PWL were significantly higher than the control group (1.37 (0.27) mg dL vs. 0.49 (0.61) mg dL, < 0.001), whereas CAT activities were significantly higher in the control group (106.6 (54.5) kU L vs. 78.3 (67.8) kU L, = 0.003). The findings of the present study revealed that oxidative stress plays a key role in the pathogenesis of welders' lung disease. Plasma thiol-disulfide homeostasis and IMA levels might be indicators of oxidative stress in PWL.
焊工肺疾病是指混合接触焊接烟尘中的不同种类的金属和化学物质，影响呼吸道和实质的所有部位。本研究旨在通过巯基-二硫键平衡和缺血修饰白蛋白（IMA）水平来研究焊工肺（PWL）患者的氧化状态。研究招募了患有焊工肺疾病的男性焊工和健康个体。测定了血浆中二硫键、二硫键/天然巯基比、二硫键/总巯基比、IMA 和过氧化氢酶（CAT）的水平。比较了两组的肺功能测试参数。PWL 和对照组的巯基-二硫键平衡参数如下：二硫键（20.5 ± 6.3 对 16.2 ± 3.9 μmol/L， ＜0.001）、二硫键/天然巯基（4.36（1.59）对 4.0（1.64）， = 0.024）和二硫键/总巯基（4.01（1.34）对 3.71（1.41）， = 0.024）。PWL 中的 IMA 水平明显高于对照组（1.37（0.27）mg/dL 对 0.49（0.61）mg/dL， ＜0.001），而对照组中的 CAT 活性明显较高（106.6（54.5）kU/L 对 78.3（67.8）kU/L， = 0.003）。本研究的结果表明，氧化应激在焊工肺疾病的发病机制中起关键作用。血浆巯基-二硫键平衡和 IMA 水平可能是 PWL 中氧化应激的指标。
