新生儿黄疸中的硫醇-二硫键稳态、血清铁氧化酶活性和血清缺血修饰白蛋白水平
Thiol-Disulfide Homeostasis, Serum Ferroxidase Activity, and Serum Ischemia Modified Albumin Levels in Neonatal Jaundice.
作者信息
Topal Ismail, Mertoglu Cuma, Surucu Kara Ilknur, Siranli Gulsah, Gok Gamze, Erel Özcan
机构信息
a Pediatrics, Erzincan University Faculty of Medicine, Erzincan, Turkey.
b Clinical Biochemistry, Erzincan University Faculty of Medicine, Erzincan, Turkey.
出版信息
Fetal Pediatr Pathol. 2019 Apr;38(2):138-145. doi: 10.1080/15513815.2018.1561772. Epub 2019 Feb 11.
AIM
Hyperbilirubinemia causes oxidative stress.
METHOD
We evaluated three oxidative stress markers in hyperbilirubinemic neonates (native/total thiol levels, serum ferroxidase activity and ischemia modified albumin (IMA), comparing these levels to levels in a control group to determine which indicators were the most sensitive.
RESULTS
Serum from 124 term infants (67 with pathologic jaundice and 57 controls) were evaluated. Native/total thiol ratio was significantly lower (p:0.021) while disulfide levels were significantly higher (p:0.001) in the jaundiced group. There was no significant difference in ferroxidase (p:0.603) or IMA (p:0.251) levels.
CONCLUSION
Altered thiol/disulfide homeostasis in the favor of disulfide indicates augmented oxidative stress in jaundiced term infants. The lack of alteration in ferroxidase or IMA levels suggests these latter alterations take more time or more severe oxidative stress to become altered or are not as sensitive as the thiol/disulfide ratio to detect oxidative stress states.
目的
高胆红素血症会引发氧化应激。
方法
我们评估了高胆红素血症新生儿的三种氧化应激标志物（天然/总巯基水平、血清铁氧化酶活性和缺血修饰白蛋白（IMA）），并将这些水平与对照组进行比较，以确定哪些指标最敏感。
结果
对124名足月儿的血清进行了评估（67名患有病理性黄疸，57名作为对照）。黄疸组的天然/总巯基比率显著降低（p：0.021），而二硫键水平显著升高（p：0.001）。铁氧化酶（p：0.603）或IMA（p：0.251）水平无显著差异。
结论
巯基/二硫键稳态向二硫键方向改变表明足月儿黄疸时氧化应激增强。铁氧化酶或IMA水平未发生改变，提示这些改变需要更长时间或更严重的氧化应激才会出现，或者在检测氧化应激状态时不如巯基/二硫键比率敏感。
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