Minakami H, Abe N, Oka N, Kimura K, Tamura T, Tamada T
Department of Obstetrics and Gynecology, Jichi Medical School, Tochigi-ken, Japan.
Endocrinol Jpn. 1988 Apr;35(2):303-10. doi: 10.1507/endocrj1954.35.303.
To evaluate the prevalence of hyperprolactinemia in patients with polycystic ovarian syndrome (PCO), 72 patients with oligo- or anovulation were studied. All of the patients had persisting elevated LH (greater than 25 mIU/ml), normal FSH, high LH/FSH ratio (greater than 2.5), and exaggerated LH responses to LHRH. Mean testosterone and androstenedione concentrations were appreciably increased in these patients. Out of 171 samples for prolactin (PRL) determination from these 72 patients, only 5 patients had a PRL value above 30 ng/ml during the first sampling. The next sampling from these same 5 women disclosed that they were transiently hyperprolactinemic because the next samples showed a normal PRL value. To further investigate the PRL secretory capacity 500 micrograms of TRH and 10 mg of metoclopramide (MCP) were administered to these 72 and 44 patients, respectively. The PRL response to MCP was significantly blunted in these patients compared to normal women while the PRL response to TRH in these patients was not indistinguishable from that in normal women. These results indicate that the true prevalence rate of hyperprolactinemia in PCO may be low rather than high and the association of hyperprolactinemia with PCO may be coincidental rather than a pathogenically related phenomenon.
为评估多囊卵巢综合征（PCO）患者高催乳素血症的患病率，对72例排卵稀少或无排卵的患者进行了研究。所有患者的促黄体生成素（LH）持续升高（大于25 mIU/ml），促卵泡生成素（FSH）正常，LH/FSH比值高（大于2.5），且对促黄体生成素释放激素（LHRH）的LH反应亢进。这些患者的睾酮和雄烯二酮平均浓度明显升高。在这72例患者的171份催乳素（PRL）测定样本中，首次采样时只有5例患者的PRL值高于30 ng/ml。对这5名女性的再次采样显示，她们是短暂性高催乳素血症，因为下次样本显示PRL值正常。为进一步研究PRL分泌能力，分别对这72例和44例患者给予500微克促甲状腺激素释放激素（TRH）和10毫克甲氧氯普胺（MCP）。与正常女性相比，这些患者对MCP的PRL反应明显减弱，而这些患者对TRH的PRL反应与正常女性并无差异。这些结果表明，PCO患者高催乳素血症的实际患病率可能较低而非较高，高催乳素血症与PCO的关联可能是巧合而非致病相关现象。
