Division of Infectious Diseases, University of Michigan Medical School, 1500 E. Medical Dr., South University Hospital F4005, Ann Arbor, MI, 48109-5378, USA.
Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA.
Mycopathologia. 2019 Oct;184(5):667-670. doi: 10.1007/s11046-019-00374-3. Epub 2019 Aug 26.
Isavuconazole is a broad-spectrum azole that is FDA-approved for the treatment of aspergillosis and mucormycosis; data on the use of isavuconazole for the treatment and prevention of other invasive fungal infections are limited. Here, we report a patient with pulmonary cryptococcosis treated with isavuconazole who experienced progression to disseminated infection with Cryptococcus while on isavuconazole. Caution is advised when using isavuconazole in situations where there is a paucity of data to recommend its use.
伊曲康唑是一种广谱唑类药物，已获得 FDA 批准用于治疗曲霉病和毛霉病；关于伊曲康唑治疗和预防其他侵袭性真菌感染的数据有限。在这里，我们报告了一例使用伊曲康唑治疗的肺隐球菌病患者，在使用伊曲康唑期间进展为播散性隐球菌感染。在数据不足推荐使用的情况下，使用伊曲康唑时应谨慎。
