Fischer Andre
Department for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Department for Systems Medicine and Brain Diseases, German Center for Neurodegenerative Diseases (DZNE) site Göttingen, Göttingen, Germany.
Curr Top Behav Neurosci. 2019;42:127-157. doi: 10.1007/7854_2019_108.
Epigenetic mechanisms have been linked to memory formation under physiological and pathological conditions. Therapeutic strategies that target the epigenetic machinery have been successfully used in preclinical studies investigating cognitive phenotypes linked to neuropsychiatric and neurodegenerative diseases. This chapter will specifically discuss the role of histone modification in the adult brain with a focus on learning and memory processes in the healthy and diseased brain. Data on dynamic changes in histone modification during memory processes as well as the most current knowledge on the corresponding enzymatic machinery in the adult brain will be summarized and discussed in the context of potential therapeutic opportunities to treat brain diseases.
表观遗传机制已被证明在生理和病理条件下与记忆形成有关。针对表观遗传机制的治疗策略已成功应用于临床前研究，这些研究探讨了与神经精神疾病和神经退行性疾病相关的认知表型。本章将具体讨论组蛋白修饰在成人大脑中的作用，重点关注健康和患病大脑中的学习和记忆过程。我们将总结和讨论记忆过程中组蛋白修饰的动态变化数据，以及成人大脑中相应酶机制的最新知识，并探讨其在治疗脑部疾病方面的潜在治疗机会。
