新型前列腺素类似物利奥前列素对环孢素所致大鼠胰腺β细胞毒性作用的预防
Prevention of toxic effects of cyclosporin on pancreatic B-cells of rats by Rioprostil, a new prostaglandin analogue.
作者信息
Müller M K, Degenhardt H, Klöppel G, Goebell H, Bergmann K, Löhr M
机构信息
Department of Medicine, University of Essen, FRG.
出版信息
Gut. 1988 Nov;29(11):1524-30. doi: 10.1136/gut.29.11.1524.
Abstract
Cyclosporin 5, 10, and 20 mg/kg bw was given to rats once daily intragastrically and caused a dose dependent, significant decrease of glucose dependent insulin release from the arterially perfused isolated pancreas, without affecting animal behaviour, weight gain, microscopic appearances of the pancreas, or kidney function. Subcutaneous injection of a new synthetic prostaglandin analogue Rioprostil 7.5 micrograms/kg bw twice daily completely prevented the effect of cyclosporin 5 mg/kg bw and protected significantly against the effects of cyclosporin 10 and 20 mg/kg bw.
摘要
以5、10和20毫克/千克体重的剂量，每天一次给大鼠灌胃环孢素，导致从动脉灌注的离体胰腺中葡萄糖依赖性胰岛素释放呈剂量依赖性显著降低，且不影响动物行为、体重增加、胰腺的微观外观或肾功能。每天两次皮下注射7.5微克/千克体重的新型合成前列腺素类似物利奥前列素，可完全预防5毫克/千克体重环孢素的作用，并显著对抗10和20毫克/千克体重环孢素的作用。
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引用本文的文献
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