Saifipour Amir, Azhari Amirhossein, Pourmoghaddas Ali, Hosseini Sayed Mohsen, Jafari-Koshki Tohid, Rahimi Mojtaba, Nasri Ali, Shishehforoush Mansour, Lahijanzadeh Ahmadreza, Sadeghian Babak, Moazam Elham, Mohebi Mohammad Bagher, Ezatian Victoria, Rabiei Katayoun, Sarrafzadegan Nizal
Cardiology Resident, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Assistant Professor, Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
ARYA Atheroscler. 2019 May;15(3):106-112. doi: 10.22122/arya.v15i3.1843.
Many studies have shown the worst effects of air pollution on cardiovascular diseases (CVDs). Present study focused on the relationship between atrial fibrillation (AF), as one of the common arrhythmias, and air pollutants in Isfahan, Iran, an industrial city in the Middle East.
A case-crossover design was used to explore the associations between air pollution and AF hospitalized patients with ventricular response (VR) > 90 beats per minute (bpm) (fast response) and those with VR ≤ 90 bpm. All patients' records were extracted from their hospital files. Air pollutants data including particulate matter less than 10 µ (PM10), PM2.5, carbon monoxide (CO), nitrogen dioxide (NO2), sulfur dioxide (SO2), and ozone (O3) were obtained from the Correlation of Air Pollution with Hospitalization and Mortality of Cardiovascular and Respiratory Diseases (CAPACITY) study. Conditional logistic regression test was used to measure the relationship between pollutants and hospitalization due to AF.
Records of 369 patients, including 173 men (46.9%) who were hospitalized for AF during the study period and had complete data were extracted. Although a positive but not statistically significant relationship was shown between 10-unit increases in all pollutants (except PM10) and the hospitalization due to AF in patients with rapid VR (RVR), the only significant relationship was observed in case of NO2 [odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.0-2.1, P = 0.031].
This study showed positive significant relationships between NO2 and the hospitalization due to AF in patients with RVR. NO2 is a greenhouse gas whose levels are expected to increase due to global environmental changes. Therefore, relevant strategies should be adopted to decrease its levels, especially in industrial cities like Isfahan.
许多研究表明空气污染对心血管疾病（CVDs）有最严重的影响。本研究聚焦于作为常见心律失常之一的心房颤动（AF）与伊朗伊斯法罕（中东的一个工业城市）空气污染物之间的关系。
采用病例交叉设计来探究空气污染与心室率（VR）>90次/分钟（bpm）（快速反应）的房颤住院患者以及VR≤90 bpm的患者之间的关联。所有患者的记录均从其医院档案中提取。空气污染物数据，包括小于10微米的颗粒物（PM10）、PM2.5、一氧化碳（CO）、二氧化氮（NO2）、二氧化硫（SO2）和臭氧（O3），来自空气污染与心血管和呼吸系统疾病住院及死亡率的相关性（CAPACITY）研究。采用条件逻辑回归检验来衡量污染物与房颤住院之间的关系。
提取了369例患者的记录，其中包括173名男性（46.9%），他们在研究期间因房颤住院且有完整数据。尽管在快速心室率（RVR）患者中，所有污染物（除PM10外）每增加10个单位与房颤住院之间呈现出正相关但无统计学意义的关系，但仅在二氧化氮的情况下观察到显著关系[比值比（OR）=1.26，95%置信区间（CI）=1.0 - 2.1，P = 0.031]。
本研究表明二氧化氮与RVR患者因房颤住院之间存在显著正相关关系。二氧化氮是一种温室气体，预计其水平会因全球环境变化而升高。因此，应采取相关策略来降低其水平，尤其是在像伊斯法罕这样的工业城市。
