采用稳定同位素示踪技术评估育龄女性对铁的生理需求。
Physiological requirements for iron in women of reproductive age assessed by the stable isotope tracer technique.
作者信息
Lu Jiaxi, Cai Jie, Ren Tongxiang, Wu Jinghuan, Mao Deqian, Li Weidong, Zhang Yu, Piao Jianhua, Wang Jun, Yang Lichen, Yang Xiaoguang, Ma Yuxia
机构信息
1The Key Laboratory of Trace Element Nutrition of The Ministry of Health, National Institute for Nutrition and Health, Chinese center for disease control and prevention, 29 Nan Wei Road, Xicheng District, Beijing, 100050 People's Republic of China.
2Hospital Management Institute, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuchang District, Wuhan, Hubei 430071 People's Republic of China.
出版信息
Nutr Metab (Lond). 2019 Aug 19;16:55. doi: 10.1186/s12986-019-0384-1. eCollection 2019.
BACKGROUND
Iron nutrition is important for the health of women of reproductive age, and defining the physiologic requirement for iron can help them accurately plan the iron intake. However, research on the physiologic requirement for iron in women is insufficient worldwide. This study aimed to further improve the methodology and get more precise data for the physiological requirements for iron in women of reproductive age on the basis of our previous study.
METHOD
Sixty-one women of reproductive age who had not been pregnant before and during the whole study were included from Hebei province, China in 2015. Each subject participated in a 2-week metabolic trial with consuming 50 mg of the stable isotope Fe, and were then followed for ~ 800 days. The abundance of Fe and the total iron concentration in the circulation were measured using multi-collector inductively-coupled plasma mass spectrometry and atomic absorption spectroscopy. The physiologic requirement for iron in women of reproductive age was then calculated.
RESULTS
The average iron circulation rate was 80.4%, and the steady period started from about 1 year. The average physiological requirement for iron of 21 subjects obtained by formula calculation was 1.55 mg/d and 23.63 μg.kg.d after adjustment for body mass, and that of 33 subjects obtained by linear regression was 1.29 mg/d, 20.98 μg.kg.d after adjustment for body mass. The results by two methods showed no significant difference. The EAR and RNI calculated from this results was 11-13 mg/d and 15-18 mg/d, respectively, both of which were slightly lower than the recommended value in Chinese Dietary Reference Intake (2013).
CONCLUSION
The physiological requirements for iron in women of reproductive age were in accordance with other studies, while the EAR and RNI calculated from which were slightly lower than Chinese present recommended value.
TRIAL REGISTRATION
ChiCTR, ChiCTR-OCH-14004302. Registered 14 February 2014, http://www.chictr.org.cn/enindex.aspx.
背景
铁营养对育龄妇女的健康至关重要，确定铁的生理需求量有助于她们准确规划铁摄入量。然而，全球范围内关于女性铁生理需求量的研究并不充分。本研究旨在在前一项研究的基础上进一步改进方法，获取更精确的育龄女性铁生理需求量数据。
方法
2015年从中国河北省纳入61名在整个研究期间未曾怀孕的育龄妇女。每位受试者参与了一项为期2周的代谢试验，摄入50毫克稳定同位素铁，然后随访约800天。使用多接收电感耦合等离子体质谱仪和原子吸收光谱法测量循环中铁的丰度和总铁浓度。随后计算育龄女性铁的生理需求量。
结果
铁的平均循环率为80.4%，稳定期从大约1年开始。通过公式计算得出的21名受试者铁的平均生理需求量，在根据体重调整后为1.55毫克/天和23.63微克/千克·天，通过线性回归得出的33名受试者在根据体重调整后为1.29毫克/天和20.98微克/千克·天。两种方法的结果无显著差异。据此结果计算得出的EAR和RNI分别为11 - 13毫克/天和15 - 18毫克/天，均略低于《中国居民膳食营养素参考摄入量（2013版）》中的推荐值。
结论
育龄女性铁的生理需求量与其他研究结果一致，但其计算得出的EAR和RNI略低于中国目前的推荐值。
试验注册
中国临床试验注册中心，ChiCTR - OCH - 14004302。于2014年2月14日注册，http://www.chictr.org.cn/enindex.aspx 。
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