Maruyama Nobuyuki, Sasaki Takanobu, Arasaki Akira, Matsuzaki Akiko, Nakasone Toshiyuki, Teruya Takao, Matayoshi Akira, Maruyama Tessho, Karube Kennosuke, Fujita Jiro, Yoshimi Naoki, Kuniyoshi Yukio, Nishihara Kazuhide
Department of Oral and Maxillofacial Functional Rehabilitation, Graduate School of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan.
Department of Thoracic and Cardiovascular Surgery, University Hospital of The Ryukyus, Nishihara, Okinawa 903-0215, Japan.
Oncol Lett. 2019 Sep;18(3):2777-2788. doi: 10.3892/ol.2019.10675. Epub 2019 Jul 26.
The occurrence of second primary tumor (SPT)following malignancy treatment is common. In patients with head and neck (H&N) cancer, SPTs principally occur in the H&N region, lungs or esophagus. Therefore, patient follow-up after cancer treatment is important in order to detect recurrence, metastasis and new primary tumors. However, no standard guidelines on lifelong follow-up imaging are available. Herein, we report a patient who presented with three metachronous primary tumors-squamous cell carcinoma (SCC) of the tongue, SCC of the lip and type A thymoma. The third tumor was incidentally detected during follow-up using contrast-enhanced computed tomography (CT) 9 years following resection of the second tumor. To the best of our knowledge, this specific combination of metachronous tumors has not yet been reported. Based on the literature review, we observed that thymoma occurs following H&N cancer treatment. Therefore, to ensure that the presence of subsequent thymomas is not overlooked, we suggest regular lifelong follow-up using contrast-enhanced CT in patients who had previously been diagnosed with H&N cancer. The literature review revealed that thymomas occur in patients with H&N cancer and should be detected at the earliest convenience.
恶性肿瘤治疗后发生第二原发性肿瘤（SPT）很常见。在头颈部（H&N）癌患者中，SPT主要发生在H&N区域、肺部或食管。因此，癌症治疗后的患者随访对于检测复发、转移和新的原发性肿瘤很重要。然而，目前尚无关于终身随访成像的标准指南。在此，我们报告一名患者，其出现了三个异时性原发性肿瘤——舌鳞状细胞癌（SCC）、唇SCC和A型胸腺瘤。第三个肿瘤是在第二个肿瘤切除9年后，通过增强计算机断层扫描（CT）随访时偶然发现的。据我们所知，这种特定的异时性肿瘤组合尚未见报道。基于文献综述，我们观察到胸腺瘤在H&N癌治疗后发生。因此，为确保不遗漏后续胸腺瘤的存在，我们建议对先前诊断为H&N癌的患者定期进行终身增强CT随访。文献综述显示，胸腺瘤发生在H&N癌患者中，应尽早发现。
