Fan Jianlin, Liu Wei, Zhang Mingzhi, Xing Chungen
Department of Stomatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.
Department of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.
Oncol Lett. 2019 Sep;18(3):3265-3273. doi: 10.3892/ol.2019.10609. Epub 2019 Jul 12.
Oral cancer is very common, occurring on head as well as neck region with poor prognosis. The X-ray repair cross-complementing group 3 gene contained in DNA repairing pathway has been investigated for its functional role in oral cancer. Nevertheless, the corresponding results are inconclusive. This study investigated the association of Thr241Met polymorphism regarding oral cancer risk. Article and literature searches were performed using Embase, Medline, PubMed, Wanfang and China National Knowledge Infrastructure (CNKI) databases with a manual search. The keywords of ' or X-ray repair cross complementing protein 3', 'polymorphism or SNP', 'oral cancer or oral squamous cell carcinoma' and their combinations were used to search literature. In accordance with the criteria of inclusion, we focused on only case-and-control studies with the distribution of genotypes and alleles being available to be extracted. Systematic meta-analysis was conducted via the STATA software (version 11.0). After a comprehensive literature collection and review, 1,615 oral cancer cases and 1,897 matched controls extracted from 7 articles were included for this meta-analysis. Our results show that only Met/Met (TT) genotype with the recessive model was associated with high risk of oral cancer (CC + CT vs. TT, OR=1.81, P=0.001, 95% CI=1.28-2.567). A significant relationship was identified under both homozygous and recessive model in Asians (CC vs. TT: OR=2.15, 95% CI=1.107-4.170, P=0.024; CT + CC vs. TT: OR=2.140, 95% CI=1.105-4.144, P=0.024), but not among Caucasians (P>0.05). The results indicate that 241Met allele might be a potential factor for oral cancer risk, particularly among Asian population. A further study using a larger population and more ethnicities should be performed to confirm the findings.
口腔癌非常常见，发生于头部和颈部，预后较差。DNA修复途径中包含的X射线修复交叉互补组3基因在口腔癌中的功能作用已得到研究。然而，相应的结果尚无定论。本研究调查了Thr241Met多态性与口腔癌风险的关联。使用Embase、Medline、PubMed、万方和中国知网（CNKI）数据库进行文献检索，并进行人工检索。使用“X射线修复交叉互补蛋白3”、“多态性或单核苷酸多态性”、“口腔癌或口腔鳞状细胞癌”及其组合作为关键词来检索文献。根据纳入标准，我们仅关注那些能够提取基因型和等位基因分布的病例对照研究。通过STATA软件（版本11.0）进行系统的荟萃分析。经过全面的文献收集和综述，本荟萃分析纳入了从7篇文章中提取的1615例口腔癌病例和1897例匹配对照。我们的结果表明，仅隐性模型下的Met/Met（TT）基因型与口腔癌高风险相关（CC + CT vs. TT，OR = 1.81，P = 0.001，95% CI = 1.28 - 2.567）。在亚洲人中，纯合子和隐性模型下均存在显著关联（CC vs. TT：OR = 2.15，95% CI = 1.107 - 4.170，P = 0.024；CT + CC vs. TT：OR = 2.140，95% CI = 1.105 - 4.144，P = 0.024），但在白种人中无显著关联（P > 0.05）。结果表明，241Met等位基因可能是口腔癌风险的一个潜在因素，尤其是在亚洲人群中。应进行进一步的研究，纳入更多人群和更多种族以证实这些发现。
