Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, Department of Medical Research, in China Medical University Hospital, Taichung, Taiwan, R.O.C.
Graduate Institute of Clinic Medical Science, China Medical University, Taichung, Taiwan, R.O.C. Terry Fox Cancer Research Laboratory, Department of Medical Research, in China Medical University Hospital, Taichung, Taiwan, R.O.C.
Anticancer Res. 2014 Jun;34(6):2951-6.
The DNA repair gene X-ray repair cross complementing protein 3 (XRCC3) is thought to play a major role in double-strand break repair and in maintaining genomic stability. Very possibly, defective double-strand break repair of cells can lead to carcinogenesis. Therefore, a case-control study was performed to reveal the contribution of XRCC3 genotypes to individual oral cancer susceptibility. In this hospital-based research, the association of XRCC3 rs1799794, rs45603942, rs861530, rs3212057, rs1799796, rs861539, rs28903081 genotypes with oral cancer risk in a Taiwanese population was investigated. In total, 788 patients with oral cancer and 956 age- and gender-matched healthy controls were genotyped. The results showed that there was significant differential distribution among oral cancer and controls in the genotypic (p=0.001428) and allelic (p=0.0013) frequencies of XRCC3 rs861539. As for the other polymorphisms, there was no difference between case and control groups. In gene-lifestyle interaction analysis, we have provided the first evidence showing that there is an obvious joint effect of XRCC3 rs861539 genotype with individual areca chewing habits on oral cancer risk. In conclusion, the T allele of XRCC3 rs861539, which has an interaction with areca chewing habit in oral carcinogenesis, may be an early marker for oral cancer in Taiwanese.
X 射线修复交叉互补蛋白 3（XRCC3）的 DNA 修复基因被认为在双链断裂修复和维持基因组稳定性中发挥重要作用。很可能，细胞双链断裂修复缺陷会导致致癌作用。因此，进行了一项病例对照研究，以揭示 XRCC3 基因型对个体口腔癌易感性的贡献。在这项基于医院的研究中，研究了 XRCC3 rs1799794、rs45603942、rs861530、rs3212057、rs1799796、rs861539、rs28903081 基因型与台湾人群口腔癌风险的相关性。共有 788 名口腔癌患者和 956 名年龄和性别匹配的健康对照进行了基因分型。结果表明，XRCC3 rs861539 的基因型（p=0.001428）和等位基因（p=0.0013）频率在口腔癌和对照组之间存在显著差异。对于其他多态性，病例组和对照组之间没有差异。在基因-生活方式相互作用分析中，我们首次提供了证据表明，XRCC3 rs861539 基因型与个体咀嚼槟榔习惯之间存在明显的联合作用，对口腔癌风险有影响。总之，XRCC3 rs861539 的 T 等位基因与口腔癌发生中的咀嚼槟榔习惯存在相互作用，可能是台湾口腔癌的早期标志物。
