乳腺扩散光学断层扫描：一种在新辅助化疗中具有潜在可改变乳腺癌风险的生物标志物。
Diffuse optical tomography of the breast: a potential modifiable biomarker of breast cancer risk with neoadjuvant chemotherapy.
作者信息
Altoe Mirella L, Marone Alessandro, Kim Hyun K, Kalinsky Kevin, Hershman Dawn L, Hielscher Andreas H, Ha Richard S
机构信息
Department of Biomedical Engineering, Columbia University, 500 W 120th St, Mudd Bldg, ET351, New York, NY 10027, USA.
Department of Radiology, Columbia University Irving Medical Center, 622 W 168th Street, New York, NY 10032, USA.
出版信息
Biomed Opt Express. 2019 Aug 1;10(8):4305-4315. doi: 10.1364/BOE.10.004305.
Abstract
The purpose of this study is to evaluate whether a diffuse optical tomography breast imaging system (DOTBIS) can provide a comparable optical-based image index of mammographic breast density, an established biomarker of breast cancer risk. Oxyhemoglobin concentration (ctOHb) measured by DOTBIS was collected from 40 patients with stage II-III breast cancer. The tumor-free contralateral breast was used for this evaluation. We observed a moderate positive correlation between the patient's mammogram density classification and ctOHb, r = 0.486 (p = 0.001). In addition, significant reduction in ctOHb levels were noted during neoadjuvant chemotherapy treatment (p = 0.017). This observation indicates that ctOHb levels measured by DOTBIS could be a novel modifiable imaging biomarker of breast cancer risk and warrants further investigation.
摘要
本研究的目的是评估一种漫射光层析成像乳腺成像系统（DOTBIS）是否能够提供与乳腺钼靶密度相当的基于光学的图像指标，乳腺钼靶密度是一种已确立的乳腺癌风险生物标志物。从40例II - III期乳腺癌患者中收集通过DOTBIS测量的氧合血红蛋白浓度（ctOHb）。使用对侧未患肿瘤的乳房进行此评估。我们观察到患者的乳房X线照片密度分类与ctOHb之间存在中度正相关，r = 0.486（p = 0.001）。此外，在新辅助化疗治疗期间观察到ctOHb水平显著降低（p = 0.017）。这一观察结果表明，通过DOTBIS测量的ctOHb水平可能是一种新型的可改变的乳腺癌风险成像生物标志物，值得进一步研究。
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