Talebian Sepehr, Mehrali Mehdi, Taebnia Nayere, Pennisi Cristian Pablo, Kadumudi Firoz Babu, Foroughi Javad, Hasany Masoud, Nikkhah Mehdi, Akbari Mohsen, Orive Gorka, Dolatshahi-Pirouz Alireza
Intelligent Polymer Research Institute ARC Centre of Excellence for Electromaterials Science AIIM Facility University of Wollongong NSW 2522 Australia.
Illawarra Health and Medical Research Institute University of Wollongong Wollongong NSW 2522 Australia.
Adv Sci (Weinh). 2019 Jun 14;6(16):1801664. doi: 10.1002/advs.201801664. eCollection 2019 Aug 21.
Given their durability and long-term stability, self-healable hydrogels have, in the past few years, emerged as promising replacements for the many brittle hydrogels currently being used in preclinical or clinical trials. To this end, the incompatibility between hydrogel toughness and rapid self-healing remains unaddressed, and therefore most of the self-healable hydrogels still face serious challenges within the dynamic and mechanically demanding environment of human organs/tissues. Furthermore, depending on the target tissue, the self-healing hydrogels must comply with a wide range of properties including electrical, biological, and mechanical. Notably, the incorporation of nanomaterials into double-network hydrogels is showing great promise as a feasible way to generate self-healable hydrogels with the above-mentioned attributes. Here, the recent progress in the development of multifunctional and self-healable hydrogels for various tissue engineering applications is discussed in detail. Their potential applications within the rapidly expanding areas of bioelectronic hydrogels, cyborganics, and soft robotics are further highlighted.
鉴于其耐久性和长期稳定性，自愈合水凝胶在过去几年中已成为有前途的替代品，可取代目前在临床前或临床试验中使用的许多脆性水凝胶。为此，水凝胶韧性与快速自愈合之间的不相容性仍未得到解决，因此，大多数自愈合水凝胶在人体器官/组织动态且对机械性能要求较高的环境中仍面临严峻挑战。此外，根据目标组织的不同，自愈合水凝胶必须具备包括电学、生物学和机械性能在内的多种性能。值得注意的是，将纳米材料掺入双网络水凝胶中作为一种可行的方法，有望制备出具有上述特性的自愈合水凝胶。在此，详细讨论了用于各种组织工程应用的多功能自愈合水凝胶的最新进展。还进一步强调了它们在生物电子水凝胶、赛博格有机物和软机器人等快速发展领域的潜在应用。
