Hajissa Khalid, Zakaria Robaiza, Suppian Rapeah, Mohamed Zeehaida
Department of Medical Microbiology & Parasitology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Biomedicine Program, School of Health Sciences, Universiti Sains Malaysia 16150 Kubang Kerian, Kelantan, Malaysia.
J Adv Vet Anim Res. 2019 Mar 24;6(2):174-182. doi: 10.5455/javar.2019.f329. eCollection 2019 Jun.
Despite the significant progress in the recent efforts toward developing an effective vaccine against toxoplasmosis, the search for new protective vaccination strategy still remains a challenge and elusive goal because it becomes the appropriate way to prevent the disease. Various experimental approaches in the past few years showed that developing a potential vaccine against the disease can be achievable. The combination of multi-epitopes expressing different stages of the parasite life cycle has become an optimal strategy for acquiring a potent, safe, and effective vaccine. Epitope-based vaccines have gained attention as alternative vaccine candidates due to their ability of inducing protective immune responses. This mini-review highlights the current status and the prospects of vaccine development along with the application of epitope-based vaccine in the future parasite immunization as a novel under development and evaluation strategy.
尽管最近在开发有效的抗弓形虫病疫苗方面取得了重大进展，但寻找新的保护性疫苗接种策略仍然是一项挑战和难以实现的目标，因为这是预防该疾病的合适方法。过去几年的各种实验方法表明，开发一种针对该疾病的潜在疫苗是可以实现的。表达寄生虫生命周期不同阶段的多表位组合已成为获得一种有效、安全和高效疫苗的最佳策略。基于表位的疫苗因其诱导保护性免疫反应的能力而作为替代疫苗候选物受到关注。本综述重点介绍了疫苗开发的现状和前景，以及基于表位的疫苗在未来寄生虫免疫中作为一种正在开发和评估的新型策略的应用。
