IRB Barcelona, BIST, Carrer de Baldiri Reixac, 10, 08028 Barcelona, Spain.
CRG, BIST, Carrer del Dr. Aiguader, 88, 08003 Barcelona, Spain.
Sci Adv. 2019 Aug 14;5(8):eaaw7965. doi: 10.1126/sciadv.aaw7965. eCollection 2019 Aug.
The notable male predominance across many human cancer types remains unexplained. Here, we show that l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.
许多人类癌症类型中显著的男性优势仍未得到解释。在这里，我们表明 l(3)mbt 脑肿瘤在男性中比女性更具侵袭性，更常发展为恶性肿瘤。通过定量蛋白质组学，我们已经鉴定出在男性和女性肿瘤样本之间差异表达的蛋白质特征。其中突出的是保守的染色质阅读器 PH 结构域蛋白 7 (Phf7)。我们表明，耗竭减少了性别依赖性基因表达差异，并抑制了男性肿瘤增强的恶性特征。我们的结果确定了性别相关肿瘤二态性的潜在调节剂，并表明这些基因可能作为抑制性别相关恶性特征的靶点。
