Sato Kiminori, Chitose Shun-Ichi, Sato Kiminobu, Sato Fumihiko, Kurita Takashi, Umeno Hirohito
Department of Otolaryngology-Head and Neck Surgery Kurume University School of Medicine Kurume Japan.
Laryngoscope Investig Otolaryngol. 2019 Jun 21;4(4):405-409. doi: 10.1002/lio2.285. eCollection 2019 Aug.
There is growing evidence to suggest that the cells in the maculae flavae of the vocal fold mucosa are tissue stem cells of the human vocal fold. This study investigated the metabolic activity of the cells in the maculae flavae of the human vocal fold from the aspect of mitochondrial microstructure.
Histologic analysis of the human vocal folds.
Five normal human adult vocal folds obtained from autopsy cases were investigated under transmission electron microscopy.
Mitochondria were randomly distributed in the cytoplasm of the cells. The morphological features of the mitochondria consisted of a double-membrane-bounded body containing matrices and a system of cristae. In each mitochondria, the lamellar cristae were sparse. The intercristal space was occupied by a mitochondrial matrix which contained electron-dense matrix granules, mitochondrial DNA, and ribonucleoprotein granules. Some mitochondria spread out over or fused to the surface of a lipid droplet in the cytoplasm. In addition, both the mitochondrial outer and inner membranes and the membranes of the lipid droplets had disappeared. Some close association between mitochondria and rough endoplasmic reticulum was present.
The features of the mitochondria of the cells in the maculae flavae of the human vocal fold suggested that their metabolic activity and oxidative phosphorylation were low and that they may have shifted to the utilization of lipids to some extent for their metabolic needs.
NA.
越来越多的证据表明，声带黏膜黄色斑中的细胞是人类声带的组织干细胞。本研究从线粒体微观结构方面研究了人类声带黄色斑中细胞的代谢活性。
对人类声带进行组织学分析。
对5例取自尸检病例的正常成人声带进行透射电子显微镜检查。
线粒体随机分布于细胞胞质中。线粒体的形态特征为包含基质和嵴系统的双膜包被体。每个线粒体中，板层嵴稀疏。嵴间空间被线粒体基质占据，基质中含有电子致密的基质颗粒、线粒体DNA和核糖核蛋白颗粒。一些线粒体伸展到细胞质中脂滴表面或与之融合。此外，线粒体的外膜和内膜以及脂滴的膜均消失。线粒体与粗面内质网之间存在一些紧密联系。
人类声带黄色斑中细胞线粒体的特征表明，其代谢活性和氧化磷酸化水平较低，且可能在一定程度上转向利用脂质来满足代谢需求。
无。
