Mermerci Başkan Bedriye, Yurdakul Fatma Gül, Aydın Ezgi, Sivas Filiz, Bodur Hatice
Department of Physical Medicine and Rehabilitation, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Turk J Phys Med Rehabil. 2017 Apr 4;64(1):1-7. doi: 10.5606/tftrd.2018.986. eCollection 2018 Mar.
This study aims to investigate the effect of serum levels of 25 hydroxyvitamin D (25(OH)D) in patients with primary knee osteoarthritis (OA) and to assess its relationship with the radiographic grading and functional status.
Serum 25(OH)D levels were measured in 107 patients (90 females, 17 males; mean age 63.0±9.6 years; range, 40 to 86 years) with primary knee OA. Radiographic grading was based on the Kellgren-Lawrence Grading Scale and the Osteoarthritis Research Society International (OARSI) Atlas Grading Scale, while the functional status was assessed using the Lequesne indices and Turkish version of the Knee Injury and Osteoarthritis Outcome Score-Physical Function Short-Form (KOOS-PS). Pain was evaluated using the Visual Analog Scale for Pain (VAS-Pain). Data including age, sex, disease duration, body mass index (BMI), and pain severity were recorded.
The mean 25(OH)D level was 13.4±10.6 ng/mL, and 90 patients (84.1%) had vitamin D deficiency. The presence of severe osteophytes was observed in 67 patients (62.6%) and 85 patients (79.4%) had Grade 2-3 joint space narrowing (JSN). The mean KOOS-PS and Lequesne scores were 40.1±12.3 and 12.9±3.6, respectively. There was no correlation between serum 25(OH)D levels and functional status.
Our study results show that serum 25(OH)D level is not related to the severity of the radiographic knee OA grading or to the functional assessment. Age and BMI are the factors affecting the radiological knee OA severity, while age, sex, BMI, and pain severity are the main determinants of the functional status.
本研究旨在调查原发性膝关节骨关节炎（OA）患者血清25羟维生素D（25(OH)D）水平的影响，并评估其与放射学分级和功能状态的关系。
对107例原发性膝关节OA患者（90例女性，17例男性；平均年龄63.0±9.6岁；范围40至86岁）测定血清25(OH)D水平。放射学分级基于Kellgren-Lawrence分级量表和国际骨关节炎研究学会（OARSI）图谱分级量表，而功能状态则使用Lequesne指数和膝关节损伤与骨关节炎结果评分-身体功能简表（KOOS-PS）的土耳其语版本进行评估。使用视觉模拟疼痛量表（VAS-疼痛）评估疼痛。记录包括年龄、性别、病程、体重指数（BMI）和疼痛严重程度在内的数据。
25(OH)D平均水平为13.4±10.6 ng/mL，90例患者（84.1%）存在维生素D缺乏。67例患者（62.6%）观察到严重骨赘，85例患者（79.4%）存在2-3级关节间隙狭窄（JSN）。KOOS-PS和Lequesne评分的平均值分别为40.1±12.3和12.9±3.6。血清25(OH)D水平与功能状态之间无相关性。
我们的研究结果表明，血清25(OH)D水平与膝关节OA放射学分级的严重程度或功能评估无关。年龄和BMI是影响膝关节OA放射学严重程度的因素，而年龄、性别、BMI和疼痛严重程度是功能状态的主要决定因素。
