At time of writing: General Hospital Trbovlje, Rudarska cesta 9, 1420 Trbovlje, Slovenia.
At time of publication: Division of Surgery, Department of Abdominal Surgery, University Medical Centre Ljubljana, Zaloška c. 2, 1000 Ljubljana, Slovenia.
Pharmacogenomics. 2019 Aug;20(12):879-890. doi: 10.2217/pgs-2019-0058.
We investigated if polymorphisms influence metabolic parameters and risk for vascular complications in Type 2 diabetes (T2D) patients. T2D patients were genotyped for rs7840156, rs2271900 and rs4871827. We built low homology model of DEPTOR to check the position of two investigated substitutions within the protein 3D structure. Carriers of polymorphic rs4871827 A allele had higher HDL cholesterol than noncarriers (p = 0.008). Risk for macrovascular and microvascular complications was increased in rs4871827 GG normal genotype carriers (p = 0.006 and p = 0.021, respectively). Low homology model of DEPTOR has shown that p.Ser389Asn substitution resulting from rs4871827 polymorphism is located at the interaction surface with mTOR. Our data suggest role of polymorphism in T2D vascular complication. First draft submitted: xxx; Accepted for publication: xxx; Published online: TBC.
我们研究了 多态性是否会影响 2 型糖尿病（T2D）患者的代谢参数和血管并发症风险。T2D 患者对 rs7840156、rs2271900 和 rs4871827 进行了基因分型。我们构建了 DEPTOR 的低同源模型，以检查这两个研究替换在蛋白质 3D 结构中的位置。与非携带者相比，多态性 rs4871827 A 等位基因携带者的高密度脂蛋白胆固醇更高（p=0.008）。rs4871827 GG 正常基因型携带者的大血管和微血管并发症风险增加（p=0.006 和 p=0.021，分别）。DEPTOR 的低同源模型表明，由 rs4871827 多态性引起的 p.Ser389Asn 替换位于与 mTOR 相互作用的表面。我们的数据表明 多态性在 T2D 血管并发症中的作用。初稿提交：xxx；已接受发表：xxx；在线发表：TBC。
