Suppr超能文献

高脂血症小鼠高血糖与颈动脉粥样硬化的遗传关联。

Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.

机构信息

Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA.

Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.

出版信息

Genes (Basel). 2022 Mar 14;13(3):510. doi: 10.3390/genes13030510.

Abstract

Type 2 diabetes (T2D) is a major risk for atherosclerosis and its complications. -null () mouse strains exhibit a wide range of variations in susceptibility to T2D and carotid atherosclerosis, with the latter being a major cause of ischemic stroke. To identify genetic connections between T2D and carotid atherosclerosis, 145 male F2 mice were generated from LP/J and BALB/cJ mice and fed 12 weeks of a Western diet. Atherosclerotic lesions in the carotid arteries, fasting, and non-fasting plasma glucose levels were measured, and genotyping was performed using miniMUGA arrays. Two significant QTL (quantitative trait loci) on chromosomes (Chr) 6 and 15 were identified for carotid lesions. The Chr15 QTL coincided precisely with QTL for fasting and non-fasting glucose levels. Carotid lesion sizes showed a trend toward correlation with fasting and non-fasting glucose levels in F2 mice. The Chr15 QTL for carotid lesions was suppressed after excluding the influence from fasting or non-fasting glucose. Likely candidate genes for the causal association were , , and . These results demonstrate a causative role for hyperglycemia in the development of carotid atherosclerosis in hyperlipidemic mice.

摘要

2 型糖尿病(T2D)是动脉粥样硬化及其并发症的主要危险因素。-null() 小鼠品系表现出对 T2D 和颈动脉粥样硬化易感性的广泛差异,后者是缺血性中风的主要原因。为了确定 T2D 和颈动脉粥样硬化之间的遗传联系,从 LP/J 和 BALB/cJ 小鼠中产生了 145 只雄性 F2 小鼠,并喂食 12 周的西方饮食。测量了颈动脉粥样硬化病变、空腹和非空腹血糖水平,并使用 miniMUGA 阵列进行了基因分型。在第 6 和 15 号染色体上鉴定出两个与颈动脉病变相关的显著 QTL(数量性状位点)。Chr15 QTL 与空腹和非空腹血糖水平的 QTL 完全吻合。在 F2 小鼠中,颈动脉病变的大小与空腹和非空腹血糖水平呈趋势相关。排除空腹或非空腹血糖的影响后,Chr15 颈动脉病变 QTL 受到抑制。可能的候选基因是、和。这些结果表明,高血糖在高脂血症小鼠颈动脉粥样硬化的发展中起因果作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8f9/8950324/9b6bc3113ff4/genes-13-00510-g001.jpg

相似文献

1
Genetic Connection between Hyperglycemia and Carotid Atherosclerosis in Hyperlipidemic Mice.
Genes (Basel). 2022 Mar 14;13(3):510. doi: 10.3390/genes13030510.
3
Genetic Evidence for a Causal Relationship between Hyperlipidemia and Type 2 Diabetes in Mice.
Int J Mol Sci. 2022 May 31;23(11):6184. doi: 10.3390/ijms23116184.
4
Genetic connection of carotid atherosclerosis with coat color and body weight in an intercross between hyperlipidemic mouse strains.
Physiol Genomics. 2022 May 1;54(5):166-176. doi: 10.1152/physiolgenomics.00006.2022. Epub 2022 Apr 6.
6
Self-monitoring of blood glucose in patients with type 2 diabetes mellitus who are not using insulin.
Cochrane Database Syst Rev. 2012 Jan 18;1(1):CD005060. doi: 10.1002/14651858.CD005060.pub3.
8
Glucose-lowering agents for treating pre-existing and new-onset diabetes in kidney transplant recipients.
Cochrane Database Syst Rev. 2017 Feb 27;2(2):CD009966. doi: 10.1002/14651858.CD009966.pub2.

引用本文的文献

本文引用的文献

1
Identification of Mep1a as a susceptibility gene for atherosclerosis in mice.
Genetics. 2021 Dec 10;219(4). doi: 10.1093/genetics/iyab160.
2
Identification of four novel QTL linked to the metabolic syndrome in the Berlin Fat Mouse.
Int J Obes (Lond). 2022 Feb;46(2):307-315. doi: 10.1038/s41366-021-00991-3. Epub 2021 Oct 23.
3
Hyperlipidemia Influences the Accuracy of Glucometer-Measured Blood Glucose Concentrations in Genetically Diverse Mice.
Am J Med Sci. 2021 Sep;362(3):297-302. doi: 10.1016/j.amjms.2021.06.014. Epub 2021 Jun 29.
4
Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.
Circulation. 2021 Feb 23;143(8):e254-e743. doi: 10.1161/CIR.0000000000000950. Epub 2021 Jan 27.
5
Regional Variation in Genetic Control of Atherosclerosis in Hyperlipidemic Mice.
G3 (Bethesda). 2020 Dec 3;10(12):4679-4689. doi: 10.1534/g3.120.401856.
6
Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease.
Circ Res. 2020 May 22;126(11):1526-1548. doi: 10.1161/CIRCRESAHA.119.316065. Epub 2020 May 21.
7
Genetic linkage of oxidative stress with cardiometabolic traits in an intercross derived from hyperlipidemic mouse strains.
Atherosclerosis. 2020 Jan;293:1-10. doi: 10.1016/j.atherosclerosis.2019.11.034. Epub 2019 Dec 3.
8
Genome-wide recombination map construction from single individuals using linked-read sequencing.
Nat Commun. 2019 Sep 20;10(1):4309. doi: 10.1038/s41467-019-12210-9.
9
polymorphisms influence late complications in Type 2 diabetes patients.
Pharmacogenomics. 2019 Aug;20(12):879-890. doi: 10.2217/pgs-2019-0058.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验