From the *Department of Anesthesiology †The Saul R. Korey Department of Neurology, Dominick P. Purpura Department of Neuroscience ‡The Saul R. Korey Department of Neurology, Department of Pediatrics §The Saul R. Korey Department of Neurology, Department of Pediatrics, Department of Epidemiology & Population Health, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York.
Anesth Analg. 2020 Jun;130(6):e161-e164. doi: 10.1213/ANE.0000000000004380.
Seizures and interictal epileptiform discharges (IEDs) have been described during sevoflurane. We prospectively estimated their incidence in 54 otherwise neurologically healthy infants by obtaining the full-head video electroencephalogram (EEG). No infants had clinical seizures, but 1 had an electrographic seizure; 3 others had focal IEDs (7.4%; 95% confidence interval [CI], 2.1%-17.9%). We detected no differences in demographic or clinical characteristics between normal and abnormal EEG groups. Diffuse slowing was the most common initial EEG change followed by fast (α, β) activity in all head leads. Larger studies with more statistical power are needed to further investigate the hypotheses generated with this research.
七氟醚麻醉期间可出现癫痫发作和发作间期癫痫样放电（IED）。我们通过全头视频脑电图（EEG）前瞻性评估了 54 例无神经系统疾病的健康婴儿的发生率。无临床癫痫发作，但 1 例出现电癫痫发作；3 例出现局灶性 IED（7.4%；95%置信区间[CI]，2.1%-17.9%）。我们在正常和异常 EEG 组之间未发现人口统计学或临床特征的差异。弥漫性减慢是最常见的初始 EEG 改变，随后所有头部导联均出现快速（α、β）活动。需要更大样本量的进一步研究来进一步验证该研究提出的假说。
